余星昕-全讯国际

余星昕  博士

副教授

800全讯白菜官方网站的联系方式

邮箱：xxyu@ecust.edu.cn

传真：021-64252431

通讯地址：上海市徐汇区梅陇路130号318信箱

邮编：200237

个人简介

2012年6月获复旦大学有机化学博士学位，上海市优秀毕业生。毕业后赴美国明尼苏达大学(university of minnesota)药学院从事小分子肺癌抑制剂研发的博士后研究。2013年8月加入华东理工大学药学院，开展药物小分子设计合成及其作用机制研究。2015年9月晋升副教授，同年被聘为硕士生导师。

作为项目负责人，主持国家自然科学基金（青年基金），主持教育部基本科研业务费探索研究基金（2项）；2014年入选上海市“浦江人才计划” 和上海市首批“青年科技英才扬帆计划”；2015年被评为华东理工大学“青年英才引进与培育计划”骨干和2015年度“药学院优秀青年教师”。

已在org. lett.; j. org. chem.; chem. commun.; chem. eur. j.; chem. soc. rev.等国际核心期刊上发表sci论文40余篇，论文被引用1000余次，h指数22。获得中国发明专利授权1项。

主要研究方向

基于新技术、新方法和新反应的新型杂环化合物的设计合成，构建具有生物活性的类天然小分子化合物用于创新药物研究。

近期发表论文

1. hua deng,‡ renmeng jia,‡ wu-lin yang, xingxin yu*, wei-ping deng*. chem. commun., 2019, 55, 7346-7349. ([‡] equal contribution)

ligand-controlled switch in diastereoselectivities: catalytic asymmetric construction of spirocyclic pyrrolidine-azetidine/oxe(thie)tane derivatives.

2. jinbin zhu, linwei huang, wei dong, naikai li, xingxin yu, wei-ping deng*, wenjun tang*. angew. chem. int. ed., 10.1002/anie.201910008.

enantioselective rhodium-catalyzed addition of arylboroxines to n-unprotected ketimines: efficient synthesis of cipargamin.

3. renmeng jia, jiang meng, jiaying leng, xingxin yu*, wei-ping deng*. chem. asian. j., 2018, 13, 2360-2364.

rhodium(ii)-catalyzed reaction of 1-tosyl-1,2,3-triazoles with morita-baylis-hillman adducts: synthesis of 3,4-fused pyrroles.

4. jiang meng, renmeng jia, jiaying leng, min wen, xingxin yu*, wei-ping deng*. org. lett., 2017, 19, 4520-4523.

carbon-carbon bond formation by reaction of rhodium azavinylcarbenes with secondary amides: access to indigo analogues from isatins.

5. jiang meng, min wen, shiwei zhang, peiwen pan, xingxin yu*, wei-ping deng*. j. org. chem., 2017, 82, 1676-1687. (highlighted by synfacts, 2017, 13, 354.)

unexpected o-h insertion of rhodium-azavinylcarbenes with n-acylhydrazones: divergent synthesis of 3,6-disubstituted- and 3,5,6-trisubstituted-1,2,4-triazines.

6. jiang meng, xiangfeng ding, xingxin yu*, wei-ping deng. tetrahedron, 2016, 72, 176-183.

synthesis of 2,5-epoxy-1,4-benzoxazepines via rhodium(ii)-catalyzed reaction of 1-tosyl-1,2,3-triazoles and salicylaldehydes.

7. bo zhou^{[ ]}, xingxin yu^{[ ]}, chunlin zhuang*, peter villalta, yong lin, junxuan lu, chengguo xing*. chemmedchem, 2016, 11, 1436-1445. (^{[ ]} equal contribution)

unambiguous identification of β-tubulin as the direct cellular target responsible for the cytotoxicity of chalcone by photoaffinity labeling.

8. linwei huang, jinbin zhu, guangjun jiao, zheng wang, xingxin yu, wei-ping deng*, wenjun tang*. angew. chem. int. ed., 2016, 55, 4527-4531. (highlighted by synfacts, 2016, 12, 557.)

highly enantioselective rhodium-catalyzed addition of arylboroxines to simple aryl ketones: efficient synthesis of escitalopram.

9. fu-sheng he, jing-hai jin, zhong-tao yang, xingxin yu, john s. fossey, wei-ping deng*. acs catal., 2016, 6, 652-656. (highlighted by synfacts, 2016, 12, 390.)

direct asymmetric synthesis of β-bis-aryl-α-amino acid esters via enantioselective copper-catalyzed addition of p-quinone methides.

10. wu-lin yang, chun-yan li, wen-jing qin, fei-fei tang, xingxin yu, wei-ping deng*. acs catal., 2016, 6, 5685-5690. (highlighted by synfacts, 2016, 12, 1058.)

cu(i)-catalyzed chemoselective and stereoselective [3 3] cycloaddition of azomethine ylides with 2-indolylnitroethylenes: facile access to highly substituted tetrahydro-γ-carbolines.

11. wu-lin yang, fei-fei tang, fu-sheng he, chun-yan li, xingxin yu*, wei-ping deng*. org. lett., 2015, 17, 4822-4825. (highlighted by synfacts, 2015, 11, 1285.)

asymmetric construction of spirocyclic pyrrolidine-thia(oxa)zolidinediones via n,o-ligand/cu(i) catalyzed 1,3-dipolar cycloaddition of azomethine ylides with 5-alkylidene thia(oxa)zolidine-2,4-diones.

12. fu-sheng he, han zhu, zheng wang, ming gao, xingxin yu*, wei-ping deng*. org. lett., 2015, 17, 4988-4991. (highlighted by synfacts, 2015, 11, 1284.)

asymmetric construction of 3,4-diamino pyrrolidines via chiral n,o-ligand/cu(i) catalyzed 1,3-dipolar cycloaddition of azomethine ylides with β-phthalimidonitroethene.

13. zheng wang^{[ ]}, xingxin yu*^{[ ]}, bo-xue tian, daniel t. payne, wu-lin yang, yang-zi liu, john s. fossey, wei-ping deng*. chem. eur. j., 2015, 21, 10457-10465.

chiral n,o-ligand/cu(oac)₂ catalyzed asymmetric construction of 4-aminopyrrolidine derivativesvia 1,3-dipolar cycloaddition of azomethine ylides with α-phthalimidoacrylates.

14. wu-lin yang, yang-zi liu, shuai luo, xingxin yu*, john s. fossey, wei-ping deng*. chem. commun., 2015, 51, 9212-9215. (highlighted by synfacts, 2015, 11, 738.)

the copper-catalyzed asymmetric construction of a dispiropyrrolidine skeleton via 1,3-dipolar cycloaddition of azomethine ylides to α

15. fei-fei tang, wu-lin yang, xingxin yu*, wei-ping deng*. catal. sci. technol., 2015, 5, 3568-3575.

cu(oac)₂/foxap complex catalyzed construction of 2,5-dihydropyrrole derivatives via asymmetric 1,3-dipolar cycloaddition of azomethine ylides with ethynyl ketones.

16. shan-shan jiang, qin-chang xu, ming-yu zhu, xingxin yu*, wei-ping deng*. j. org. chem., 2015, 80, 3159-3169.

kinetic resolution of α-methylene-β-hydroxy esters catalyzed by acyl transfer catalyst an-piq.

17. shan-shan jiang, bo-qi gu, ming-yu zhu, xingxin yu*, wei-ping deng*. tetrahedron, 2015, 71, 1187-1191.

nonenzymatic kinetic resolution of α-aryl substituted allylic alcohols catalyzed by acyl transfer catalyst np-piq.

18. wen-jing qin, yi li, xingxin yu*, wei-ping deng*. tetrahedron, 2015, 71, 1182-1186.

tbai/tbhp catalyzed direct n-acylation of sulfoximines with aldehydes.

19. jiang meng, di wu, ying shi, xingxin yu*, wei-ping deng. tetrahedron, 2015, 71, 1074-1079.

construction of 1h-pyrrol-2-ylphosphonates via [3 2] cycloaddition of phosphate azomethine ylides with ynones.

20. xianbo wang, xingxin yu*. j. org. chem., 2014, 79, 7854-7860.

silver(i) and copper(i) co-catalyzed tandem reaction of 2-alkynylbenzaldoximes with aldehydes or alcohols: approach to 4-carboxylated isoquinolines.

21. shanshan jiang, bin hu, xingxin yu*, weiping deng*. chin. j. chem., 2014, 32, 694-698.

fc-pip catalyzed asymmetric synthesis of cis-2,3-dihydrobenzofurans.

22. yong luo, xiaolin pan, xingxin yu*, jie wu*. chem. soc. rev., 2014, 43, 834-846.

double carbometallation of alkynes: an efficient strategy for the construction of polycycles.