曹松-全讯国际

中文 | english

曹 松 教授  博士  (prof. dr. song cao)

 

电话021-64253452传真021-64252603   

地址:华东理工大学实验十八楼1423

e-mail:

 


个人简介

华东理工大学药学院教授、博士生导师。分别在华东师范大学化学系、南京大学化学化工学院、华东理工大学化学与制药学院获得学士、硕士、博士学位。2000年起在华东理工大学化学与制药学院从事科研与教学工作。2006.42007.4以访问学者身份赴美国西北大学化学系从事帕金森药物的设计与合成。2013.72013.10以高级访问学者身份赴英国南安普顿大学化学系从事药物的设计与合成。

作为项目负责人承担了上海科委科技创新和攻关项目;负责国家自然科学基金面上项目三项:合成含二氟甲基(cf2)的结构多样性小分子的新策略、“过渡金属催化的多氟芳烃的碳氟键的活化:碳氢化及官能团化”以及“基于碳氟键和碳氢键活化的碳碳偶联反应”;负责十二五科技支撑计划一项;作为课题组副组长负责国家863一项课题(第一、滚动、加强)以及国家973的子课题一项。

以主要作者在国际核心学术期刊如chem communorg lettchem. eur. j.adv synth catalchemcatchemj org. chemgreen chemeur. j org. chemtetrahedronorg biomol chemtetrahedron lettsynlettj agric and food chemj fluorine chem发表论文七十多篇;授权国家发明专利五项,公开中国发明专利10项、国际专利一项。现指导博士和硕士研究生多名。

201810月起担任国际学术期刊j fluorine chem的编委会成员(editorial board)

tetrahedrontetrahedron lettersorg biomol chemchem commj org. chemorg chem front,j fluorine chemj agric food chemorg lettadv synth catal及化学学报、有机化学、中国化学等期刊的审稿人。


研究方向

1.碳氟键的活化及官能团化;新型含氟砌块的多组分反应;含氟活性化合物的合成

2.作用靶标特异的仿生农药化学:昆虫生长调节剂(苯甲酰脲类几丁质抑制剂、具有蜕皮激素活性的非甾醇类二芳酰肼类化合物);含恶二唑哒嗪酮类化合物拒食剂;鱼尼丁受体氟虫双酰胺、氯虫苯甲酰胺类化合物。

3.高效有机合成方法学(新型多组分反应的设计;多组分反应在农药、医药中的应用;点击化学参与的多组分反应)


欢迎报考农药点博士生和硕士研究生!



获奖成果

ø“芳香杂环及含氟仿生农药的分子设计、合成制备及构效关系”获2003年度教育部自然科学一等奖(第二完成人)

ø含氟芳香精细化学品及氟化试剂的关键技术、理论与应用及产业化”获2008度国家科技进步奖二等奖(第四完成人)


代表性论著

以下为近期以通讯作者发表的论文:

2019

facile synthesis of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles by the cyclization of gem-difluoroalkenes with acyl hydrazides

xuxue zhang,* jingjing he and song cao*

asian j of org chem, 2019, 8, 279–282

  

镍催化的偕二氟芳基乙烯与有机锌交叉偶联反应立体选择性合成(z)-单氟烯烃

张娟, 王碧云, 刘熠森, 曹松*

有机化学, 2019, 39, 249–256 (invited)

  

copper-catalyzed synthesis of gem-difluoroallylboronates from a-trifluoromethyl alkenes and b2pin2

xianghu zhao, chunmei li, biyun wang and song cao*

tetrahedron lett, 2019, 60, 129–132 

 

2018

基于碳氟键断裂的硼化反应

曹松

应用技术学报, 2018, 18 (4), 366–369 (invited,亮点介绍)


以乙腈为氰基源合成4-氰基偕二氟芳基乙烯

刘青雲, 赵祥虎, 李佳录, 曹松*

化学学报, 2018, 76, 945–950 (invited封面)



synthesis of difluoromethylated enynes by the reaction of α-(trifluoromethyl)styrenes with terminal alkynes


mingsheng wu, xianghu zhao, yisen liu, and song cao*

org biomol chem, 2018, 16, 6909–6917


lihmds-promoted palladium or iron-catalyzed ipso-defluoroborylation of fluoroarenes

xianghu zhao, mingsheng wu, yisen liu, and song cao*

org lett, 2018, 20(18), 5564−5568  (分别被公众号cgb资讯、有机合成路线分享、康龙化成、synfacts报道)

a facile synthesis of 3-arylindenes by hmpa-promoted direct arylation of indenes with aryl fluorides

xinfei ji, jialu li, mingsheng wu, song cao*

acs omega, 2018, 3, 10099−10106 (invited)


direct c(sp3)−h difluoroallylation of diarylmethanes with a-(trifluoromethyl) styrenes at room temperature

xinfei ji, yisen liu, hongyan shi, song cao*

tetrahedron, 2018, 74, 4511−4519 (invited)


fabrication of charge-conversion nanoparticles for cancer imaging by flash nanoprecipitation

meng li, yisheng xu*, jinli sun, mingwei wang, dahai yang, xuhong guo, haiyun song, song cao*, yunfeng yan*

acs appl. mater. interfaces, 2018, 10, 10752−10760      if: 8.097 (合作论文)


stereoselective copper- or nickel-catalyzed tertiary, secondary, and primary alkylation of monofluoroalkenes with grignard reagents

hongyan shi, wenpeng dai, biyun wang, song cao*

organometallics, 2018, 37(3), 459–463    

  

cu-catalyzed tertiary alkylation of α-(trifluoromethyl)styrenes with tertiary alkylmagnesium reagents

wenpeng dai, yingyin lin,yan wan, song cao*

org chem front, 2018, 5, 55–58

  

2017

bismuth(iii)-promoted trifluoromethylthiolation of pyrazolin-5-ones with trifluoromethanesulfanamide

qingyun liu, tao huang, xianghu zhao, jingjing wu*, song cao*

acs omega, 2017, 2, 7755–7759 (invited)

  

hmpa-promoted siladifluoromethylation of di-, and triarylmethanes with ruppert−prakash reagent

xinfei ji, xianghu zhao, hongyan shi, song cao*

chem - an asian j, 2017, 12, 2794–2798



direct copper-catalyzed oxidative trifluoromethylthiolation of aryl boronic acids with agscf3

wei wu, biyun wang, xinfei ji, song cao*

org. chem. front., 2017, 4, 1299–1303

  

cu-catalyzed stereoselective borylation of gem-difluoroalkenes with b2pin2

juan zhang, wenpeng dai, qingyun liu, song cao*

org lett, 2017, 19(12), 3283−3286

  

synthesis of n,n-disubstituted 2-aminothiophenes by the cyclization of gem-difluoroalkenes with b-keto thioamides

xuxue zhang, mingsheng wu, juan zhang, song cao*

org biomol chem, 2017, 15, 2436–2442

  

n-butyllithium-mediated synthesis of n-aryl tertiary amines by reactions of fluoroarenes with secondary amines at room temperature

yingyin lin, meng li, xinfei ji, jingjing wu*,song cao*

tetrahedron, 2017, 73, 1446–1472

  

recent advances in the synthesis and c–f functionalization of gem-difluoroalkenes

xuxue zhang, song cao*

tetrahedron letters, 2017, 58, 375–392 (invited)

  

2016

lda-mediated synthesis ofortho-cyanated diarylmethanes by reaction of fluoroarene with arylacetonitrile at room temperature

fang liang, xinfei ji, juan zhang, song cao*

org. chem. front., 2016, 3, 1425−1429

  

sterically controlled cu-catalyzed or transition-metal-free cross-coupling of gem-difluoroalkenes with tertiary, secondary, and primary alkyl grignard reagents

wenpeng dai, hongyan shi, xianghu zhao, song cao*

org lett, 2016, 18(17), 4284−4287

  

mild and copper-free stereoselective cyanation of gem-difluoroalkenes by using benzyl nitrile as a cyanating reagent

juan zhang, chengyuan xu, wei wu, song cao*

chem. eur. j. 2016, 22, 9902–9908

  

silver-mediated anti-markovnikov and markovnikov-selective hydrotrifluoromethylthiolation of terminal alkynes

wei wu, wenpeng dai, xinfei ji, song cao*

org lett, 2016, 18(12), 2918–2921

  

synthesis of exocyclic trisubstituted alkenes via nickel-catalyzed kumada type cross-coupling reaction of gem-difluoroalkenes with di-grignard reagents

wenpeng dai, xuxue zhang, juan zhang, yingyin lin, song cao*

adv synth catal, 2016, 358, 183187


synthesis of fluorovinyl pyrazolyl (thio)ethersby the reaction of gem-difluoroalkenes with pyrazolin-5-ones (thiones)

tao huang, xianghu zhao, xinfei ji, wei wu, song cao*

j fluorine chem, 2016, 182, 61–68

  

2015

lda-mediated synthesis of triarylmethanes by arylation of diarylmethanes with fluoroarenes at room temperature

xinfei ji, tao huang, wei wu, fang liang, song cao*

org lett, 2015, 17(20), 5069–5099


mild and metal-free trifluoromethylation and pentafluoroethylation of gem-difluoroalkenes with tmscf3 and tmscf2cf3

guanyi jin, xuxue zhang, dan fu, wenpeng dai, song cao*

tetrahedron, 2015, 71, 7892–7899


metal-free one-pot sequential direct diarylation of pyrazolin-5-ones with diaryliodonium salts

tao huang, xinfei ji, wei wu, fang liang, song cao*

rsc advances, 2015, 5, 66598–66601


nickel-catalyzed suzuki-miyaura type cross-coupling reactions of (2,2-difluorovinyl)benzene derivatives with arylboronic acids

yang xiong, tao huang, xinfei ji, jingjing wu*, song cao*

org biomol chem, 2015, 13, 7389–7392


mild electrophilic trifluoromethylthiolation of ketones with trifluoromethanesulfanamide

wei wu, xuxue zhang, fang liang, song cao*

org biomol chem, 2015, 13, 6992–6999


copper-catalyzed coupling cyclization of gem-difluoroalkenes with activated methylene carbonyl compounds: facile domino access to polysubstituted furans

xuxue zhang, wenpeng dai, wei wu, song cao*

org lett, 2015, 17(11), 2708–2711


synthesis of monofluoroalkenes through selective hydrodefluorination of gem-difluoroalkenes with red-al®

jingjing wu,* juan xiao, wenpeng dai, song cao*

rsc advances, 2015, 5, 34498–34501


perfluorobutyliodide-assisted direct cyanomethylation of azoles and phenols with acetonitrile

juan zhang, wei wu, xinfei ji, song cao*

rsc advances, 2015, 5, 20562–20565


synthesis of fluorovinyl aryl ethers by a three component reaction of gem-difluoroalkenes with arylboronic acids and oxygen

mingjin wang, fang liang, yang xiong, song cao*

rsc advances, 2015, 5, 11996–11999


base-mediated direct fluoroalkenylation of 2-phenyl-1,3,4-oxadiazole, benzothiazole and benzoxazole with gem-difluoroalkenes

xuxue zhang, yingyin lin, juan zhang, song cao*

rsc advances, 2015, 5, 7905–7908


2014

stereoselective synthesis of b-fluoroenyne by the reaction of gem-difluoroalkenes with terminal alkynes

guanyi jin, juan zhang, wei wu, song cao*

j fluorine chem, 2014, 168, 240–246


synthesis of polyfluoroaryl-containing 1,2,3-triazoles by reaction of polyfluoroarenes, sodium azide and active methylene ketones/esters

jingjing wu,* dan fu, song cao*

j fluorine chem, 2014, 168, 230–235


palladium- or nickel-catalyzed kumada cross-coupling reaction of gem-difluoroalkenes and monofluoroalkenes with grignard reagents

wenpeng dai, juan xiao, guanyi jin, jingjing wu *, song cao *

j org chem, 2014, 79,10537–10546


copper-free direct ch trifluoromethylation of acetanilides with sodium trifluoromethanesulfinate

mingxi wu, xinfei ji, wenpeng dai, song cao*

j org chem, 2014, 79, 8984–8989


synthesis of n-(a-fluorovinyl)azoles by the reaction of difluoroalkenes with azoles

yang xiong, xuxue zhang, tao huang, song cao*

j org chem, 2014, 79, 6395–6402, featured article, cover


nickel-catalyzed n-heterocycle directed cross-coupling of fluorinated arenes with organozinc reagents

senhan xiao, yang xiong, xuxue zhang, song cao*

tetrahedron, 2014, 70, 44054411


2013

copper-mediated trifluoromethylation of 5-iodotriazole with (trifluoromethyl)trimethylsilane promoted by silver carbonate

dan fu, jian zhang, song cao*

j fluorine chem, 2013, 156, 170–176


copper(i)-catalyzed trifluoromethylation of phthalic anhydride derivatives with (trifluoromethyl)trimethylsilane

mingxi wu, mingjin wang, song cao*

chin j chem,2013, 31, 945-949 (ranked as the second most accessed papers in top 15 in july, 2013)

(invited, dedicated to the special fluorine chemistry)


transition-metal-free sonogashira-type cross-coupling of alkynes with fluoroarenes

guanyi jin, xuxue zhang, song cao*

org lett, 2013, 15 (12), 3114–3117

(this paper was highlighted in synfacts, 2013, 9, 1115)


non-catalytic pyridyl-directed alkylation and arylation carbon-fluorine bond of polyfluoroarenes with grignard reagents

yang xiong, jingjing wu, senhan xiao, juan xiao, song cao*

j org chem, 2013, 78(9), 4599–4603


novel synthesis of 1,4,5-trisubstituted 1,2,3-triazoles via a one-pot three-component reaction of boronic acids, azides and active methylene ketones

jian zhang, guanyi jin, senhan xiao, jingjing wu, song cao*

tetrahedron, 2013, 69, 23522356


nicl2(pcy3)2-catalyzed hydrodefluorination of fluoroarenes with lial(o-t-bu)3h

juan xiao, jingjing wu, wenwen zhao, song cao*

j fluorine chem, 2013, 146, 7679


2012

one-pot three component synthesis of polyfluoroarylated arylacetates via vnsar-snar reaction

yang xiong, jingjing wu, senhan xiao, song cao*

chin j chem,2012, 30, 2747–2751


(invited, dedicated to the 60th anniversary of east china university of science and technology)

one-pot, three-component synthesis of 1,4,5-trisubstituted 1,2,3-triazoles starting from primary alcohols

guanyi jin, jian zhang, dan fu, jingjing wu, song cao*

eur j org chem, 2012, 5446–5449


synthesis of  through nickel-promoted  and oxygen

jian zhang, jingjing wu, yang xiong, song cao*

chem commun, 2012, 48, 8553–8555


oxidation of benzylic methylenes to ketones with oxone-kbr in aqueous acetonitrile under transition metal free conditions

lixia yin, jingjing wu, juan xiao, song cao*

tetrahedron letters, 2012, 53, 4418–4421


synthesis and insecticidal activities of novel analogues of flubendiamide containing a hexafluoroisopropanol moiety

mingxi wu, wenwen zhao, guanyi jin, qingchun huang, song cao*

chin j chem2012, 30, 1310–1314

(invited, dedicated to professor jun zhou on the occasion of his 80th birthday)


highly efficient nicl2/nicl2(pcy3)2 co-catalyzed hydrodefluorination of fluoroarenes and trifluorotoluenes with superhydride

wenwen zhao, jingjing wu, song cao*

adv synth catal, 2012, 354(4), 574578


synthesis of difluoromethyl-containing α-acyloxycarboxamide derivatives through a passerini reaction and desulfonylation

jingjing wu, wenwen zhao, song cao*

eur j org chem, 2012, 1380–1387


2011

wenwen zhao, hui li, jian zhang, song cao*

chin j chem,29, 27632768

(invited, dedicated to professor weiyuan huang on the occasion of his 90th birthday)

  

nickel-catalyzed hydrodefluorination of fluoroarenes and trifluorotoluenes with superhydride (lithium triethylborohydride)

jingjing wu and song cao*

chemcatchem, 2011, 3(10), 15821586


novel synthesis of pseudopeptides bearing a difluoromethyl group by ugi reaction and desulfanylation

jingjing wu, hui li, song cao*

beilstein j org chem, 2011, 7, 1070–1074

(invited, thematic series: multicomponent reaction)


zncl2-catalyzed hydrodefluorination of gem-difluoromethylene derivatives with lithium aluminum hydride

jianhang cheng, jingjing wu, song cao*

, 2011, 52, 3481–3484


novel synthesis of difluoromethyl-containing 1,4-disubstituted 1,2,3-triazoles via a click-multicomponent reaction and desulfanylation strategy

jian zhang, jingjing wu, li shen, guanyi jin, song cao*

adv synth catal, 2011, 353(4), 580–584


one-pot synthesis of difluoromethyl-containing dihydropyrimidinones catalyzed by yb(pfo)3 under solvent and dehydrating agent free conditions

mingxi wu, jinlong yu, wenwen zhao, jingjing wu, song cao*

j fluorine chem, 2011, 132, 155–159


non-catalytic conversion of c-f bonds of gem-difluoromethylene derivatives to c-h bonds with lithium aluminum hydride e

jingjing wu, jianhang cheng, jian zhang, li shen, xuhong qian, song cao*

tetrahedron, 2011, 67, 285288


2010

k2co3-assisted one-pot sequential synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5-dicarboxylates under solvent-free conditions

li shen, song cao*, jingjing wu, hui li, jian zhang, mingxi wu, xuhong qian*

tetrahedron letters, 2010, 51, 4866–4869


a mild and efficient synthesis of monofluorinated a-lactam pseudopeptides via a novel dehydrofluorination of ugi products

nianjin liu, song cao*, jingjing wu, li shen, jinlong yu, jian zhang, hui li, xuhong qian*

mol divers, 2010, 14, 501–506


an efficient three-component domino synthesis of difluoromethyl-containing 1,4-dihydropyridines under solvent and catalyst free conditions

hui li, jinlong yu, song cao*, li shen, mingxi wu, jianhang cheng, xuhong qian*

, 2010, 53(7), 1509–1513


antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent l-type ca2  channels cav1.3 and cav1.2

che-chien chang, song cao, soosung kang, li kai, xinyong tian, prativa pandey, sara f. dunne, chi-hao luan, d. james surmeier, richard b. silverman(第二作者)

bioorg med chem, 2010, 18, 31473158


a general strategy for construction of difluoromethyl compound library and its application in synthesis of pseudopeptides bearing terminal difluoromethyl group

jingjing wu, song cao*, nianjin liu, li shen, jinlong yu, jian zhang, hui li and xuhong qian

org biomol chem, 2010, 8, 2386–2391


synthesis and insecticidal activity of heptafluoroisopropyl-containing benzoylphenylurea structures

jian zhang, xiuhong tang, isaac ishaaya, song cao*, jingjing wu, jinlong yu, hui li, xuhong qian

, 2010, 58(5), 27362740


2009

multicomponent reactions based on fluoro-containing  building blocks

jingjing wu and song cao*

curr org chem, 2009, 13(18), 17911840

(invited, guest editor, thematic series: multicomponent reaction)


a revisit to the hantzsch reaction: unexpected products beyond 1,4-dihydropyridines

li shen,song cao*, jingjing wu, jian zhang, hui li, nianjin liu and xuhong qian*

green chemistry, 2009, 11, 1414–1420


new gem-difluoromethylene-containing isocyanide as a useful building block for the synthesis of difluorinated pseudopeptides via ugi reaction

nianjin liu, song cao* li shen, jingjing wu, jinlong yu, jian zhang, hui li, xuhong qian*

tetrahedron letters, 2009, 50, 1982–1985


2008

one-pot synthesis of trifluoromethyl-containing pyrazoles via sequential yb(pfo)3- catalyzed three-component reaction and ibx-mediated oxidation

li shen, jian zhang, song cao*, jinlong yu, nianjin liu, jingjing wu, xuhong qian*

synlett 2008, 19, 3058–3062


ytterbium (iii) perfluorooctanoate-catalyzed one-pot three-component synthesis of fully substituted pyrazoles under solvent-free conditions

li shen, song cao*, nianjin liu, jingjing wu, xin feng, xuhong qian*

synlett 2008, 9, 1341–1344


one-pot three component synthesis of heteroaryled arylacetates via vnsar-sn reaction using n-methylpyrrolidone as general solvent

song cao*, jingjing wu, lina li, longjie zhu, jian zhang, jinlong yu, xuhong qian

org biomol chem, 2008, 6 (7), 1293–1297


solvent-free ugi four-component condensation: application to synthesis of philanthotoxins-12 analogues

nianjin liu, song cao*, jingjing wu, jinlong yu, li shen, xin feng and xuhong qian*

tetrahedron, 2008, 64(18), 3877–4142


synthesis of thiohydantoins under one-pot three-component solvent-free conditions

song cao*, longjie zhu, chuanmeng zhao, xiuhong tang, huajun sun, xin feng, xuhong qian

monatshefte fur chemie, 2008, 139, 923-926


2007-2001

an efficient and practical method for the synthesis of 1-(2,6-difluorobenzoyl)-3-[2’-alkyl-3’-oxopyridazin-4’- yl]ureas as potential chitin synthesis inhibitors

song cao*, deli lu, chuanmeng zhao, linali, qingchun huang, xuhong qian*

monatshefte fur chemie, 2006, 137(6), 779–784


syntheses, antifeedants and qsar analysis of new oxa(thia)diazolyl 3(2h)-pyridazinones

song cao*, na wei, chuanmeng zhao, lina li, qingchun huang, xuhong qian*

j of agric and food chem, 2005, 53, 3120–3125


synthesis and antifeedant activity of new oxadiazolyl 3(2h)-pyridazinones

song cao, xuhong qian*, gonghua song, bing chai, zhisheng jiang

j of agric and food chem, 2003, 51, 152–155


synthesis of 3-aryl-1,3,5-pentanetricarboxylic acid trialkyl esters via a tandem addition- rearrangement-addition reaction

song cao*, zheng zhang, ailong fan,ziming huang

monatshefte fur chemie, 2003, 134, 529–532


syntheses and insecticidal activity of new 2-(5-(trifluoromethyl)pyridyloxymethyl)-1,3,4– oxadiazoles

song cao, xuhong qian*, gonghua song, qingchun hung

j of fluorine chem, 2002, 117, 63–66


n’-tert-butyl-n’-aroyl-n-(alkoxycarbonylmethyl)-n-aroylhydrazines, a novel nonsteroidal ecdysone agonist: syntheses , conformational and crystal structure analysis

song cao, xuhong qian*, gonghua song

canadian j of chem, 2001, 79, 272–278


a novel and practical amination of 4,5-dichloropyridazinones via hydrazine hydrate reduction

song cao, xuhong qian*, gonghua song, xiayu huang

chemistry letters, 2001, 1, 54–55


专利:

含七氟异丙基苯甲酰脲类化合物及其用途

曹松,钱旭红, 唐秀红, 黄青春, 孙华君, 张建

发明专利申请号:2008 1003 4794.8,申请日:2008318

公开号:cn 1015 38227  a,公开日:2009923

授权专利号:zl 2008 1 0034794.8,授权公告日:201266


benzoylurea compounds bearing heptafluoroisopropyl and uses thereof

song cao, xuhong qian, xiuhong tang, jian zhang, qingchun huang, huajun sun

国际申请号:pct/cn2009/070858,国际申请日:2009318

国际公布号:wo/2009/115040 a1,国际公布日:2009924


2’-羟基六氟异丙基的邻苯二甲酰胺类化合物及其用途

曹松, 吴明熹, 黄青春, 尹黎霞, 吴晶晶

发明专利申请号:2011 1019 1776.2,申请日:20110711

公布号:cn 1023 20998  a,公布日:2012118

授权专利号:zl 2011 1 0191776.2,授权公告日:2014820


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