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梁欣 博士
副教授，硕士生导师
邮箱：
地址：上海市徐汇区梅陇路130号实验十八楼633室；
邮编：200237
个人简历：
2003.9-2007.6 华东理工大学生物工程专业，工学学士
2007.9-2012.3 华东理工大学生物化工专业，工学博士
2012.7-2015.5 美国埃默里大学（emory university）renhao li’s lab 博士后
2015.7-2016.8 华东理工大学药学院，讲师
2016.9至今 华东理工大学药学院，副教授
作为项目负责人主持国家自然科学基金，上海市自然科学基金，教育部基本科研业务费探索研究基金等。已在journal of hematology & oncology，molecular therapy，british journal of cancer，arterioscler thromb vasc biol等国际sci期刊发表论文36篇，sci他引500余次。
研究方向：
主要研究领域为肿瘤转移以及微环境的相互作用研究。包括血小板参与肿瘤转移微环境形成的机制研究，mirna在肿瘤转移以及微环境中的相互作用研究，小分子化合物或抗体药物的抗肿瘤机制研究。
代表性论文：
1. yin q, gu j, qi y, lu y, yang l, liu j*, liang x*. adam28 from both endothelium and gastric cancer cleaves von willebrand factor to eliminate von willebrand factor-induced apoptosis of gastric cancer cells. eur j pharmacol. 2021, 898:173994.
2. zhao y, tao q, li s, zheng p*, liu j, liang x*. both endogenous and exogenous mir-139-5p inhibit fusobacterium nucleatum-related colorectal cancer development. eur j pharmacol. 2020, 888:173459.
3. zhao y, xu j, le v, gong q, li s, gao f, ni l*, liu j*, liang x*. epcam aptamer-functionalized cationic liposome-based nanoparticles loaded with mir-139-5p for targeted therapy in colorectal cancer. molecular pharmaceutics. 2019, 16(11): 4696-4710.
4. xu k*, zhan y, yuan z, qiu y, wang h, fan g, wang j, li w, cao y, shen x, zhang j, liang x*, yin p*. hypoxia induces drug resistance in colorectal cancer through the hif-1α/mir-338-5p/il-6 feedback loop. molecular therapy. 2019, 27(10): 1810-1824.
5. qi y, chen w, liang x, xu k*, gu x, wu f, fan x, ren s, liu j, zhang j, li r, liu j*, liang x*. novel antibodies against gpibα inhibit pulmonary metastasis by affecting vwf-gpibα interaction. journal of hematology & oncology. 2018, 11(1):117.
6. liang x, shi h, yang l, qiu c, lin s, qi y, li j*, zhao a*, liu j*. inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells. british journal of cancer. 2017, 116(7):903-911.
7. liang x, wang j, chen w, ma x, wang y, nagao n, weng w*, huang j*, liu j*. inhibition of airway remodeling and inflammation by isoforskolin in pdgf-induced rat asmcs and ova-induced rat asthma model. biomed pharmacother. 2017, 95:275-286.
8. xu k, chen g, li x, wu x, chang z, xu j, zhu y, yin p, liang x*, dong l*. mfn2 suppresses cancer progression through inhibition of mtorc2/akt signaling. sci rep. 2017, 7:41718.
9. lin s, yang l, shi h, du w, qi y, qiu c, liang x*, shi w*, liu j*. endoplasmic reticulum-targeting photosensitizer hypericin confers chemo-sensitization towards oxaliplatin through inducing pro-death autophagy. int j biochem cell biol. 2017 jun;87: 54-68.
10. chen w1, liang x1, syed ak, jessup p, church wr, ware j, josephson cd, li r*. inhibiting gpibα shedding preserves post-transfusion recovery and hemostatic function of platelets after prolonged storage. arterioscler thromb vasc biol. 2016, 36(9):1821-1828.
11. liang x, syed ak, russell sr, ware j, li r*. dimerization of glycoprotein ib is not sufficient to induce platelet clearance. j thromb haemost. 2016,14: 381-386.
12. mao r, zou f, yang l, lin s, li y, ma m, yin p*, liang x*, liu j*. the loss of mir-139-5p promotes colitis-associated tumorigenesis by mediating pi3k/akt/wnt signaling. int j biochem cell biol. 2015, 69: 153-161.
13. liang x, russell sr, estelle s, jones lh, cho s, kahn ml, berndt mc, bunting st, ware j, li r*. specific inhibition of ectodomain shedding of glycoprotein ibα by targeting its juxtamembrane shedding cleavage site. j thromb haemost. 2013, 11(12): 2155-2162.
注：1共同第一作者， ＊通讯作者
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