张辰-全讯国际

张辰 博士

e-mail: czhang@ecust.edu.cn

地址：华东理工大学 徐汇校区实验十八楼1513

教育经历

2015/10-2018/09   图卢兹大学，化学专业，理学博士，导师：heinz gornitzka

2011/09-2014/06   华东理工大学，药学专业，医学硕士，导师：徐玉芳

2007/09-2011/06   华东理工大学，制药工程，工学学士

科研与学术工作经历

2019/01-至今    华东理工大学，药物科学系，博士后，合作导师：李洪林

2018/09-2018/12   法国国家科学研究中心药理与结构生物学研究所，博士后，合作导师：olivier cuvillier

2014/07-2015/09   中国科学院上海有机化学研究所，生命有机国家重点实验室马大为课题组，研究助理

代表性研究成果

期刊论文

(1) chen zhang; pierre-yves fortin; guillaume barnoin; xue qin; xing wang; alvaro fernandez alvarez; christian bijani; marie-lise maddelein; catherine hemmert; olivier cuvillier; and heinz gornitzka. an artemisinin-derivative–(nhc)gold(i) hybrid with enhanced cytotoxicity through inhibition of nrf2 transcriptional activity. angewandte chemie international edition, 2020, 59: 2~9

(2) chen zhang; marie-lise maddelein; raymond wai-yin sun; heinz gornitzka; olivier cuvillier; catherine hemmert, pharmacomodulation on gold-nhc complexes for anticancer applications is lipophilicity the key point?,european journal of medicinal chemistry, 2018, 157: 320~332

(3) chen zhang; sandra bourgeade delmas; alvaro fernandez alvarez; alexis valentin; catherine hemmert; heinz gornitzka,synthesis, characterization,and antileishmanial activity of neutral n-heterocyclic carbenes gold(i)complexes, european journal of medicinal chemistry, 2017, 143: 1635~1643

(4) chen zhang; catherine hemmert; heinz gornitzka; olivier cuvillier; ming zhang; raymond wai-yin sun,cationic and neutral n-heterocycliccarbene gold(i) complexes: cytotoxicity, nci-60 screening, cellular uptake, inhibition of mammalian thioredoxin reductase, and reactive oxygen speciesformation, chemmedchem, 2018, 13: 1~13

(5) rui gao; sha liao; chen zhang; weilong zhu; liyan wang; jin huang; zhenjiang zhao; honglin li; xuhong qian; yufang xu,optimization ofheterocyclic substituted benzenesulfonamides as novel carbonic anhydrase ixinhibitors and their structure activity relationship, european journal of medicinal chemistry, 2013, 62: 597~604

(6) changlong wang; jimena tuninetti; zhao wang; chen zhang; roberto ciganda; lionel salmon; sergio moya; jaime ruiz; didier astruc,hydrolysis ofammonia-borane over ni/zif 8 nanocatalyst: high efficiency, mechanism, andcontrolled hydrogen release, journal of the american chemical society, 2017, 139 (33): 11610~11615

授权发明专利

（1）马大为，俞强; 袁钧瑛; 夏宏光; 蔡东坡; 王开亮; 张辰; 夏尚华, egfr激酶抑制剂及其制备方法和应用, 2017.3.30-2037.3.29, wipo, wo 2017/049992 al

（2）李洪林; 徐玉芳; 赵振江; 黄瑾; 高瑞; 王立言; 张辰; 朱伟龙; 杨春梅, 苯磺酰胺类化合物及其用途, 2012.10.3-2032.10.2, 中国, cn102702109a

（3）徐玉芳; 赵振江; 黄瑾; 朱维平; 刘莉; 王立言; 杨春梅; 朱伟龙; 张辰; 李洪林, 磺酰胺类化合物及其用途, 2012.10.3-2032.10.2, 中国, cn102702057a