刘仁华-全讯国际

 刘仁华  教授 博士生导师
电话: 86-21-64250627 ；传真: 86-21-64250627
e-mail:
地址：上海梅陇路130号实验18楼919

 个人简介
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     60年代生于广西桂北山区融安县，幼时擅长捕鱼抓鸟，放牧经验丰富。1993年获中国科学院兰州化学物理研究所硕士学位；2000年至2006中国科学院大连化学物理研究所，从事有机合成方法学、绿色氧化及环境污染物的氧化降解方面的研究。2007年1月受聘于华东理工大学药学院，从事有机、药物合成方法学以及环境污染物降解方向的研究。2011年被广西壮族自治区党委人才工作小组聘任为广西首批特聘专家。目前以第一作者或通讯作者在j. am. chem. soc.; angew. chem. int. ed.; chem. sci ; chem. eur. j.;chem.  comm.;org lett, 以及 j. org. chem.;environ. sci. technol；adv. synth. & catal.等杂志发表论文数十篇，应邀在chem. soc. rev.撰写评论文章1篇。应邀参与全国本科医药规范教材《药物合成反应》以及全国高等医药十二五规范教材《药物合成反应》的编写。获专利20项。迄今，文章被他人引用2000余次，单篇最高被sci引用300次，其中j. am. chem. soc.; angew. chem. int. ed.; j. org. chem.三篇文章曾被angew. chem. int. ed.在highlights专栏重点评述。作为项目负责人承担国家863课题及国家自然科学基金项目3项，参与中国科学院知识创新工程重要方向项目一项。 
   

 研究方向
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1.有机合成方法学：新型有机合成反应的设计和发展；新催化剂的设计、合成及其在有机合成中的应用；精细有机中间体的工艺开发。

2. 绿色氧化：催化有氧氧化方法学的研究。主要致力于发展氧分子的有效活化及控制的新方法，着重解决催化氧化反应中催化剂的催化活性,反应选择性及催化剂的稳定性等关键科学问题。

3. 环境污染物的氧化降解：基于氧气活化的新方法及其他创新技术，设计并发展高效、绿色、便宜的氧化降解方法消减环境难降解污染物。

 
    代表性论著
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1) li jm, zhang j, li mf, zhang cy, yuan yk, liu, rh*, naphtho[2,3-b]furan-4,9-dione synthesis via palladium-catalyzed reverse hydrogenolysis, chem. commun., 55, 2348--2351, 2019

2) yang d, ji x, zhang j, zhang c, li m, li j, liu, rh*, pd/c-catalyzed dehydrogenation of 2- q1 cinnamoylbenzoic acids to 3-benzylidene-3hisochroman-1,4-diones, chem. commun., 54, 7774--7777, 2018.

3) jiang q, qi x, zhang c, ji x, li j, liu, rh*, oxidant- and hydrogen acceptor-free palladium catalyzed dehydrogenative cyclization of acylhydrazones to substituted oxadiazoles,org. chem. front., 5, 386-390, 2018.

4)  zhao x., zhou j., lin s., jin x., liu r.*, c-h functionalization via remote hydride elimination: palladium catalyzed dehydrogenation of ortho-acyl phenols to flavonoids.org. lett., 19, 976-979, 2017.(highlighted by organic chemistry portal: www.organic-chemistry.org/abstracts/lit5/757.shtm)

5) yang d., zhu y., yang n., jiang q., liu r.*, one-step synthesis of substituted benzofurans from ortho-alkenylphenols via palladium-catalyzed c-h functionalization.adv. synth. catal., 358, 1731-1735, 2016.

6)  j. zhang, q. jiang, d. yang, x. zhao, y. dong and r. liu*, reaction-activated palladium catalyst for dehydrogenation of substituted cyclohexanones to phenols and h2 without oxidants and hydrogen acceptors, chem. sci., 6, 4674-4680, 2015.

7) liu, yx; deng, ym; zavalij, py; liu, rh; doyle, mp, an efficient route to highly enantioenriched tetrahydroazulenes and beta-tetralones by desymmetrization reactions of delta,delta-diaryldiazoaceto-acetates,chem. commun., 51(3), 565-568, 2015.

8) chai, hh; guo, rq; yin, w; cheng, lp; liu, rh; chu, ch, one-pot, three-component reaction using modified julia reagents: a facile synthesis of 4,5-disubstituted 1,2,3-(nh)-triazoles in a wet organic solvent,acs comb. sci., 17(3), 147-151, 2015.

9) yin, w; chai, hh; liu, rh; chu, ch; palasota, ja; cai, xh, click n-benzyl iminodiacetic acid: novel silica-based tridentate zwitterionic stationary phase for hydrophilic interaction liquid chromatography, talanta, 132, 137-145, 2015

10) shen, jx; sun, jk; qin, ss; chu, ch; liu, rh*, 4-benzamido-tempo catalyzed oxidation of a broad range of alcohols to the carbonyl compounds with nabro3 under mild conditions,chin. j. chem., 32(5), 405-409, 2014.

11) shen, jx; yang, dj; liu, yx; qin, ss; zhang, jw; sun, jk; liu, ch; liu, cy; zhao, xm; chu, ch; liu, rh*, copper-catalyzed aerobic oxidative coupling of aromatic alcohols and acetonitrile to beta-ketonitriles, org. lett., 16(2), 350-353. 2014.(highlighted by organic chemistry portal: www.organic-chemistry.org/abstracts/lit4/327.shtm)

12)yang, jj; yin, w; liu, rh; chu, ch, ti(oi-pr)4 mediated olefination between julia reagent and aldehydes under mild conditions: facile synthesis of vinyl sulfones, j. chin. chem. soc., 60( 4), 412-417, 2013

13)jin, xk; liu, yx; lu, qq; yang, dj; sun, jk; qin, ss; zhang, jw; shen, jx; chu, ch; liu, rh*, formation of c=n bonds by the release of h2: a new strategy for synthesis of imines and benzazoles, org. biomol. chem., 11(23), 3776-3780, 2013

14)yang, jj; yin, w; liu, rh; chu, ch, facile synthesis of 4,5-disubstituted 2h-1,2,3-triazoles by catalyst-free cycloaddition between substituted vinyl sulfones and sodium azide under ambient conditions,chin. j. chem., 30(12), 2786-2790, 2012

15)guo, hy; liu, rh; yang, jj; yang, bc; liang, xm; chu, ch, a novel click lysine zwitterionic stationary phase for hydrophil2012ic interaction liquid chromatography,j. chromatogr. a, 1223, 47-52. 2012

16)lu qq, liao nc, chua ch, shen jx, liu yx, tao jw, liang xm, liu rh*. dioxygen in combination with hydrazine: a practical system for degradation of a broad spectrum of toxic organics in water. j. hazard. mater.; 192(3), 1186-1191. 2011.

17)chu ch, liu rh; application of click chemistry on preparation of separation materials for liquid chromatography; chem. soc. rev., 40, 2177-2188, 2011.

18)chu ch, liu rh*; chloralkanes as chlorinating agents: an efficient approach to acyl chlorides and destruction of chlorinated hydrocarbons; appl. catal. b: environ.; 101, 343–347, 2011.

19)tao jw, lu qq, chu ch, liu rh*, liang xm; a 4-meo-tempo, peg-no2 and hcl catalytic system for highly efficient aerobic oxidation of alcohol;synthesis; 23, 3974-3976, 2010.

20)yin wl, chu ch, lu qq, tao jw , liang xm, liu rh*;   iron chloride/4-acetamido- tempo/sodium nitrite-catalyzed aerobic oxidation of primary alcohols to the aldehydes; adv. synth. catal.; 352, 113-118, 2010.

21)zhang h, chen cy, liu rh, xu q, zhao wq; transition-metal-free highly efficient aerobic oxidation of sulfides to sulfoxides under mild conditions; molecules; 15, 83-92, 2010.

22)fu dm, peng yr, liu rh*, zhang ff, liang xm; concurrent destruction strategy: nano2-catalyzed, trichlorophenol-coupled degradation of p-nitrophenol using molecular oxygen; chemoshere; 75, 701-706, 2009.

23)zhang h, chen cy, liu rh, xu q, liu jh; dbdmh/nano2 catalyst: transition -metal-free approach to highly efficient aerobic oxidation of sulfides to sulfoxides; synth. commun.; 38, 4445-4451, 2008.

24)peng yr, fu dm, liu rh*, zhang ff, liang xm; nano2/fecl3 catalyzed wet oxidation of the azo dye acid orange 7;chemoshere; 71, 990-997, 2008.

25)xl, liu rh, jin y, liang xm; tempo/hcl/nano2 catalyst: a transition- metal-free approach to efficient aerobic oxidation of alcohols to aldehydes and ketones under mild conditions;chem. eur. j.; 14, 2679-2685, 2008.

26)peng yr, fu dm, liu rh*, zhang ff, xue xy, xu q, liang xm; nano2/fecl3 dioxygen recyclable activator: an efficient approach to active oxygen species for degradation of a broad range of organic dye pollutants in water; appl. catal. b environ.; 79, 163-170, 2008.

27)wang lz, zhang ff, liu rh*, zhang ty, xue xy, xu q, liang xm; fecl3/nano2: an efficient photocatalyst for the degradation of aquatic steroid estrogens under natural light irradiation;environ. sci. technol.; 41, 3747-3751, 2007.

28)fu dm, liu rh, xu q, xue xy, zhang ff, liang xm; kinetic study on wet air co-oxidation of phenol at presence of nitrobenzene; fres. environ. bull.; 16, 71-75, 2007.

29)wang nw, liu rh, xu q, liang xm; n-hydroxysuccinimide-promoted oxidation of primary alcohols and aldehydes to form active esters with hypervalent(iii) iodine; chem. lett.; 36, 566-567, 2006.

30)zhang gf, liu rh*, xu q, ma lx, liang xm; sodium nitrite-catalyzed oxybromination of aromatic compounds and aryl ketones with a combination of hydrobromic acid and molecular oxygen under mild conditions; adv. synth. catal.; 348, 862-866, 2006.

31)wang nw, liu rh*, chen jp, liang xm; nano2-activated, iron-tempo catalyst system for aerobic alcohol oxidation under mild conditions; chem. commun.; 42, 5322-5324, 2005.

32)liang xm, fu dm, liu rh*, zhang q, zhang ty, hu xq; highly efficient nano2 - catalyzed destruction of trichlorophenol using molecular oxygen; angew. chem. int. ed.; 44, 5520-5523, 2005.

33)liu rh, dong cy, liang xm, wang xj, hu xq; highly efficient catalytic aerobic oxidations of benzylic alcohols in water;j. org. chem.; 70, 729-731, 2005.  

34)liu rh, liang xm, dong cy, hu xq; transition-metal-free: a highly efficient catalytic aerobic alcohol oxidation process; j. am. chem. soc.; 126, 4112-4113, 2004.

35)ye jx, wang yc, liu rh, zhang gf, zhang q, chen jp, liang xm; a highly enantioselective phase-transfer catalyzed epoxidation of enones with a mild oxidant, trichloroisocyanuric acid;chem. commun.; 2714-2715, 2003.