一．简历
马磊，男，1979年生，河南辉县人，中共党员，上海市“浦江人才”，药学院副院长，药学专业责任教授，药学实验教学中心主任，教育部学位中心评审专家，上海市药学实践工作站站长，上海市药学会天然药物化学专业委员会委员，中国药学会高级会员，美国西北大学访问学者，执业药师。主要从事药物化学及新药开发工作。2007年6月毕业于中国药科大学药学专业，获理学博士学位，期间在中国科学院上海药物研究所联合培养，导师胡立宏教授和楼凤昌教授。2007年8月，入职华东理工大学药学院工作至今，历任讲师、副教授、教授、博导。2012年5月-2013年5月在美国西北大学化学系silverman教授和mirkin教授课题组从事神经系统类疾病的药物合成和dna纳米载药系统的研发工作。2015年8月-2016年8月在苏州吴中东太湖科技金融城管理局任副局长（挂职），负责人才引进和产学研对接工作。目前在journal of medicinal chemistry，european journal of medicinal chemistry，phytochemistry，cns neuroscience & therapeutics等杂志发表论文100余篇，申请国家专利16项，pct专利1项，授权6项。科研基金方面，目前作为负责人承担国家自然科学青年（1项）及面上基金（3项），上海市支撑计划，上海市浦江人才计划，上海市联盟计划以及中央高校基本科研业务费等国家和上海市项目多项。本课题组致力于基于中药及天然产物的新药开发工作，近年来成果显著，一个抗老年痴呆新药项目以3125万的价值实现转让、数个药物候选物正在与研发型的制药企业商讨开发事宜，发现多个有苗头的化合物并正在开展进一步的新药开发工作。
【研究兴趣】
基于ai的药物设计、合成及新药开发工作
天然产物基于活性和admet的结构优化和全合成
【研究疾病领域】
神经退行性疾病
炎症及器官纤维化
多药耐药癌症
代谢性疾病
【课程】
本科生：天然药物化学、天然药物化学实验、药学专业概论。
研究生：药物波谱解析、药学导论。
【荣誉及社会兼职】
药学专业责任教授（2021）
上海市药学实践工作站站长（2020）
上海市药学会天然药物化学专业委员会委员（2020）
中国药学会高级会员（2020）
指导两名高中生获评上海市青少年“科创达人”（2020）
华东理工大学青年五四奖章提名奖（2019）
苏州市人才科技工作顾问（2018）
华理附中兼职讲师（2018）
指导“知行杯”上海市大学生社会实践项目大赛三等奖，《大美寻甸，同心同行——赴云南开展常见病与常用药宣讲》（2017）
指导第七届“国药工程-东富龙杯”全国大学生制药工程设计竞赛二等奖（2017）
中国中西医结合学会虚症与老年医学专业委员会转化医学学组委员（2016）
苏州国际精英创业周评审专家（2016）
114产学研专家（2016）
“具有创新药物研究能力的药学专业人才培养体系改革与实践” 校教育教学成果二等奖（2016）
“药学实验教学中心综合管理平台建设” 校教育教学成果三等奖（2016）
华东理工大学研究生课程优秀任课教师二等奖（2016）
上海市“浦江人才”（2015）
上海市药学会中药专业委员会委员（2015）
教育部学位中心评审专家（2014）
“药学专业实验教材”校教育教学成果二等奖（2013）
华东理工大学优秀班导师（2010）
bmc、bmcl、t、tl、化学教育等国内外杂志通讯评议人
欢迎有志于药物化学、天然药物化学以及新药开发领域研究的学生加入！！
招生专业：博士【药学（主招）、制药工程与技术】；工程博士（生物与医药）；学术硕士(药学、制药工程与技术）；专业硕士（药学、生物与医药（制药工程））
二．论文专利及项目情况
【代表性论文】
1. hewen qian, yuanqing ding, xingyu deng, weiwei huang, zhenzhen li, fengling liu, jie zhang, lihui wang, junping liu, yaxia yuan, shurong hou*, xiabin chen*, lei ma*. synthesis-accessibility-oriented design of c-jun n-terminal kinase 1 inhibitor.european journal of medicinal chemistry, 2023, 256, 115442.
2. licheng zhou, yingfan liang, yi huang, guixiang yang, lulu zheng, jiamin sun, yang li, fuli zhu, hewen qian, rui wang*, lei ma*. design, synthesis and biological evaluation of diosgenin-indole derivatives as dual-functional agents for the treatment of alzheimer's disease. european journal of medicinal chemistry, 2021, 219, 113426.
3. guixiang yang, yan huang, lulu zheng, li zhang, lin su, yuhang wu, jie li, licheng zhou, jin huang, yun tang*, rui wang*, lei ma*. design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-alzheimer's disease agents. european journal of medicinal chemistry, 2020, 187, 111913.
4. huanhuan yin, jingjing dong, yingchun cai, ximeng shi, hao wang, guixia liu, yun tang*, jianwen liu*, lei ma*. design, synthesis and biological evaluation of a library of chalcones as reversers of p-glycoprotein-mediated multidrug resistance. european journal of medicinal chemistry, 2019, 180, 350-366.
5. guixiang yang, songlan ge, yan wu, jin huang, shiliang li*, rui wang*, lei ma*. design, synthesis and biological evaluation of 3-piperazinecarboxylate sarsasapogenin derivatives as potential multifunctional anti-alzheimer agents. european journal of medicinal chemistry, 2018, 156, 206-215.
【其它论文】
6. thi thanh huong le, lei ma, phu hiep hoang, van hung hoang, van khang pham*, phu hung nguyen*. anti-cancer activity of marsdenialongise a, a new c21 steroidal glycoside isolated from marsdenia longipes w.t. wang (apocynaceae).steroids, 2023, 199, 109310.
7. weidong ding, jiamin sun, lei ma*, rui wang*. mechanism of diosgenin derivative ml5 activating nrf2 signaling pathway to improve ad. journal of east china university of science and technology, 2023, 49, 1-9.
8. zhenzhu li, kai sun, yuanhong xu, fuli zhu, zhenyu mao, yang wang, yaxia yuan, ting qiu*, xiabin chen*, lei ma*. design and synthesis of indol-2-one derivatives as potential ret inhibitors. bioorganic & medicinal chemistry letters, 2023, 97, 129538.
9. xiangli he, ying huang, zhongyu xu, xi liu, zhaomin xu, lei ma, yuzheng zhao, and jin huang*. an enzyme kinetics-based laboratory module aimed at introducing undergraduates to high-throughput drug screening. journal of chemical education, 2023, 100, 3841-3848.
10. moran zhou, jiamin sun, zhuohang yu, zengrui wu, weihua li, guixia liu, lei ma*, rui wang*, yun tang*. investigation of anti-alzheimers mechanisms of sarsasapogenin derivatives by network-based combining structure-based methods. journal of chemical information and modeling, 2023, 63, 2881-2894.
11. wen zhang, fuli zhu, yi huang, xiangli he, jie li, jin huang*, lei ma*. design and synthesis of isobavachalcone derivatives as potential dihydroorotate dehydrogenase inhibitors. chemistryselect, 2023, 8, e202301331.
12. wenxuan sun, zijia liu, jian xu, ya cheng, ruixue yin, lei ma, honglin li, xuhong qian, hongbo zhang*. 3d skin models along with skin-on-a-chip systems: a critical review.chinese chemical letters, 2023, 34, 107819.
13. yichao jin, fuli zhu, jianhua li*, lei ma*. a visual analytics system toward bridging together traditional chinese medicine and modern medicine. visual informatics, 2023, 7, 41-55.
14. qun ye, ziwei jiang, ying xie, yuanhong xu, yiyi ye, lei ma*, lixia pei*. my11 exerts antitumor effects through activation of the nf-κb/puma signaling pathway in breast cancer. investigational new drugs, 2022, 40, 922-933.
15. weiwei huang, yi huang, jiayan cui, yuhang wu, fuli zhu, jin huang*, lei ma*. design and synthesis of osthole-based compounds as potential nrf2 agonists. bioorganic & medicinal chemistry letters, 2022, 61, 128547.
16. jie yang, yongyun li, chunyan zong, qianqian zhang, shengfang ge, lei ma, jiayan fan*, jianming zhang*, renbing jia*. xanthatin selectively targets retinoblastoma by inhibiting the plk1-mediated cell cycle. investigative ophthalmology & visual science, 2021, 62(15):11, 1-13.
17. zuzana bednarikov, miroslav gancar, rui wang, lulu zheng, yun tang, yating luo, yan huang, barbora spodniakova, lei ma, zuzana gazova*. extracts from chinese herbs with anti-amyloid and neuroprotective activities. internationaljournalofbiologicalmacromolecules, 2021, 179, 475-484.
18. lan jiang, guoliang zhu, jianying han, chengjian hou, xue zhang, zhixin wang, weize yuan, kangjie lv, zhanren cong, xinye wang, xiangyin chen, loganathan karthik, huanting yang, xuyuan wang, gaoyi tan, guang liu, liya zhao, xuekui xia, xiangyang liu, shushan gao, lei ma, mei liu, biao ren, huanqin dai, ronald j. quinn, tom hsiang, jingyu zhang, lixin zhang, xueting liu*. genome-guided investigation of anti-inflammatory sesterterpenoids with 5-15 trans-fused ring system from phytopathogenic fungi. applied microbiology and biotechnology, 2021, 105, 5407-5417.
19. pham van khang*, sy danh thuong, vu van nhuong, sida shen, and lei ma. two new polycyclic compounds and cytotoxic activities of ethanol and ethyl acetate extract of leaves of capparis dongvanensis (sy.) and their chemotaxonomic significance. polycyclic aromatic compounds 2021, 42, 1-7.
20. yaru hu, lei jiang, xiaoyan sun, jianqiang wu, lei ma, yanbo zhou, kuangfei lin, yi luo, changzheng cui*. risk assessment of antibiotic resistance genes in the drinking water system. science of the total environment, 2021, 800, 149650.
21. yi huang, weiwei huang, guixiang yang, rui wang*, lei ma*. design and synthesis of novel diosgenin-triazole hybrids targeting inflammation as potential neuroprotective agents. bioorganic & medicinal chemistry letters, 2021, 43, 128092.
22. guixiang yang, jiamin sun, lulu zheng, li zhang, jie li, haixian gan, yan huang, jin huang, xingxing diao, yun tang*, rui wang*, lei ma*. twin drug design, synthesis and evaluation of diosgenin derivatives as multitargeted agents for the treatment of vascular dementia. bioorganic & medicinal chemistry, 2021, 37, 116109.
23. licheng zhou, ximeng shi, huanhuan yin, yi huang, rui wang,* lei ma*. design, synthesis and biological evaluation of nobiletin derivatives as multifunctional agents for the treatment of alzheimer’s disease. chemistryselect, 2021, 6, 569-575.
24. jie li, yu mao, kexin jiang, lei ma*, rui wang*. tanshinone iia attenuates cognitive impairment via improving mitochondrial function and reducing oxidative stress. journal of east china university of science and technology, 2021, 47, 1-10.
25. li zhang, yuhang wu, guixiang yang, haixian gan, dayong sang, jiye zhou, lin su, rui wang*, lei ma*. design, synthesis and biological evaluation of novel osthole-based derivatives as potential neuroprotective agents. bioorganic & medicinal chemistry letters, 2020, 30, 127633.
26. ximeng shi, yuyu zhao, licheng zhou, huanhuan yin, jianwen liu*, lei ma*. design, synthesis and biological evaluation of dimethyl cardamonin (dmc) derivatives as p-glycoprotein-mediated multidrug resistance reversal agents. letters in drug design & discovery, 2020, 17, 1270-1282.
27. lixia pei, yiyi ye, wenshu zhao, qun ye, songlan ge, ziwei jiang, xiaoqiang liang, haixian gan, lei ma*. a validated uplc-ms/ms method for quantitative determination of a potent neuroprotective agent sarsasapogenin-aa13 in rat plasma: application to pharmacokinetic studies. biomedical chromatography, 2020, e4775.
28. pham van khang, lihong hu, lei ma*. one-pot synthesis of isoindolin-1-ones with thiamine hydrochloride (vb1) as a catalyst and their inhibitory activity against cancer cell lines. polycyclic aromatic compounds, 2020, 40, 33-39.
29. pham van khang*, hoang phu hiep, lei ma, sida shen. chemical compositions and anti-cancer activities of the volatile oils ofleaves and rhizomes of three polianthes species. letters in organic chemistry, 2020, 17, 434-437.
30. haixian gan, yuhang wu, kexin jiang, songlan ge, yuqian yao, rui wang*, lei ma*.synthesis and structure activity relationships of novel derivatives as potent neuroprotective agents and nitric oxide production inhibitors. chemistryselect, 2019, 4, 11678-11682.
31. cong zhang, yan wu, jie li, guixiang yang, lin su, yan huang, rui wang*, lei ma*. synthesis and biological evaluation of 3-carbamate smilagenin derivatives as potential neuroprotective agents. bioorganic & medicinal chemistry letters, 2019, 29, 126622.
32. ling yu, cui huang, dong dong, yan huang, lei ma*, rui wang*. neuroprotective effects of sarsasapogenin-aa13 via autophagy and mapk pathway. international journal of clinical and experimental medicine,2019, 12, 4920-4927.
33. huanhuan yin, ximeng shi, hao wang, guixia liu, lei ma*. vb1 promoted green synthesis of chalcones and its neuroprotection potency evaluation. processes, 2019, 7, 236.
34. pham van khang, nguyen thi hien lan, le quang truong, mai thi minh chau, mai xuan truong, dinh thuy van, nguyen thi quynh anh, lei ma*. isolation of new glycosides from anemarrhena asphodeloides rhizome and screening of their anticancer activity. letters in organic chemistry, 2019, 16, 474-477.
35. lixia pei, songlan ge, yiyi ye, ziwei jiang, xiaoqiang liang, wenshu zhao, lei ma*. development and validation of a uplc-ms/ms method for determination of sarsasapogenin-aa22 in rat plasma and its application to a pharmacokinetic study. biomedical chromatography, 2018, 32, e4295, 1-8.
36. minghuang hong, sai guo, kai wang, lei ma*, guobin ren*. influence factor investigation on the solution-mediated polymorphic transformation of baricitinib phosphate. zeitschrift fur anorganische und allgemeine chemie, 2018, 644, 849-855
37. pham van khang, ngo duc hieu, sida shen, lei ma*. two new steroidal glycosides from anemarrhena asphodeloides rhizome, and their cytotoxic activity in vitro. phytochemistry letters, 2018, 28, 164-167.
38. changzheng cui, qi han, lei jiang, lei ma, lei jin, dong zhang, kuangfei lin, tianyang zhang. occurrence, distribution, and seasonal variation of antibiotics in an artificial water source reservoir in the yangtze river delta, east china. environmental science and pollution research, 2018, 25, 19393-19402.
39. xiaoning li, sijia wang, yanhua lu, huanhuan yin, junhua xiao, kai li, lei ma*, yuxun zhou*. a dual fluorescence reporter system for high throughput screening of effectors of kiss1 gene expression. febs open bio., 2018, 8, 1352-1363.
40. cui huang, dong dong, qian jiao, hui pan, lei ma*, rui wang*. sarsasapogenin-aa13 ameliorates aβ-induced cognitive deficits via improving neuroglial capacity on aβ clearance and antiinflammation. cns neuroscience & therapeutics, 2017, 23, 498-509.
41. dong dong, yu mao, cui huang, qian jiao, hui pan, lei ma*, rui wang*. astrocytes mediated the nootropic and neurotrophic effects of sarsasapogenin-aa13 via upregulating brain-derived neurotrophic factor. american journal of translational research, 2017, 9, 4015-4025.
42. hui pan, pham van khang, dong dong, rui wang, lei ma*. synthesis and sar study of novel sarsasapogenin derivatives as potent neuroprotective agents and no production inhibitors. bioorganic & medicinal chemistry letters, 2017, 27, 662-665.
43. dong dong, nannan zhou, rui-xuan liu, jiawei xiong, hui pan, siqi sun, lei ma*, rui wang*. sarsasapogenin-aa13 reduces lps-induced inflammatory responses in vitro and relieves dimethylbenzene-induced ear edema in mice. acta pharmacologica sinica, 2017, 38, 699-709.
44. pham van khang, dao mai phuong, lei ma*. new steroids from anemarrhena asphodeloides rhizome and their α-glucosidase inhibitory activity. journal of asian natural products research, 2017, 19, 468-473.
45. mai xuan truong, sida shen, lei ma, pham van khang*. volatile constituents of three polianthes species flowers from viet nam and their inhibitory activity. journal of essential oil bearing plants. 2017, 20, 1157-1161.
46. jiawei xiong, songlan ge, lei ma*. extraction and purification of tanshinone ii a and salvianolic acid b from salvia miltiorrhiza bunge. natural product research and development, 2017, 29, 1396-1402.
47. yaoqi lu, jinping fu, congbin yang, baozhu qiu, jiaping le, lei ma*. investigation of the release of nifedipine from sustained-release tablets based on compaction propertiesof hydroxypropyl methylcellulose. chinese pharmaceutical journal, 2017, 52, 468-472.
48. yaoqi lu, jinping fu, hui xiong, jiaping le, lei ma*. influence mechanism of particle size of hpmc on release of theophylline from hydrophilic matrix sustained-release tablets. chinese journal of pharmaceuticals, 2017, 48, 208-214.
49. yaqin yang, songlan ge, lei ma*. synthesis of tetrahydrocarbazole derivatives using thiamine hydrochloride (vb1) as efficient catalyst. journal of east china university of science and technology, 2016, 42, 499-507.
50. jianhong zhao, ting xu, lei ma*. synthesis of apatinib mesylate. chinese journal of pharmaceuticals, 2015, 46, 449-452
51. wenhuan cheng, lei jiang, ning lu, lei ma, xiaoyan sun, yi luo, kuangfei lin changzheng cui*. development of a method for trace level determination of antibiotics in drinking water sources by high performance liquid chromatography-tandem mass spectrometry. analytical methods, 2015, 7, 1777-1787.
52. pham van khang, ting xu, liuxin xu, nannan zhou, lihong hu, rui wang*. lei ma* steroidal glycosides from marsdenia tenacissima. phytochemistry letters, 2015, 12, 54-58.
53. yongmei zhou, xianming shi, lei ma, sifang zhang*. isolation and identification of withaphysalins from physalis minima. journal of china pharmaceutical university, 2015, 46, 62-65.
54. pham van khang, zhongguo zhang, yuhui meng, dean guo, xuan liu, lihong hu*, lei ma*. cardenolides from the bark of calotropis gigantea. natural product research, 2014, 28, 1191-1196.
55. changzheng cui, lei ma, jie shi, kuangfei lin, qishi luo, yongdi liu*. metabolic pathway for degradation of anthracene by halophilicmartelella sp. ad-3. international biodeterioration & biodegradation, 2014, 89, 67-73.
56. peng liu, xing xu, lili chen, lei ma, xu shen, lihong hu*. discovery and sar study of hydroxyacetophenone derivatives as potent, non-steroidal farnesoid x receptor (fxr) antagonists. bioorganic & medicinal chemistry, 2014, 22, 1596-1607.
57. fei ma, lei ma, min lei, lihong hu*. synthesis of 1,2-disubstituted 1,2-dihydropyrrolo[3,4-b]indol-3(4h)-one derivatives. monatshefte für chemie 2014, 145, 1035-1041.
58. pham van khang, zhongguo zhang, sida shen, lei ma*, lihong hu*. a one-pot synthesis of isoindolin-1-imine derivatives. tetrahedron, 2013, 69, 10933-10939.
59. wenjuan xiang, qiqi wang, lei ma*, lihong hu*. β-orcinol-type depsides from the lichen thamnolia vermicularis. natural product research, 2013, 27, 804-808.
60. junhua liu, abdul latif, mumtaz ali, guiping zhang, wenjuan xiang, lei ma, mohammad arfan*, lihong hu*. diterpenoids from euphorbia neriifolia. phytochemistry, 2012, 75, 153-158.
61. guoping hu, xi li, xuan zhang, yaozong li, lei ma, liumeng yang, guixia liu, weihua li, jin huang, xu shen, lihong hu, yongtang zheng, yun tang*. discovery of inhibitors to block iteractions of hiv-1 integrase with human ledgf/p75 via structure-based virtual screening and bioassays. journal of medicinal chemistry, 2012, 55, 10108-10117.
62. weibin song, lingjun hu, yuhui meng, lei ma, dean guo, xuan liu, lihong hu*. the effect of vindoline c-16 substituents on the biomimetic coupling reaction: synthesis and cytotoxicity evaluation of the corresponding vinorelbine analogues. bioorganic & medicinal chemistry letters, 2012, 22, 3485–3487.
63. lixia pei, yuanwu bao, lei ma, qiqi wang, yiyi ye, xianghui han, sheng liu*, xiuping chen*. a sensitive method for determination ofplatycodin d in rat plasma using liquidchromatography/tandem mass spectrometryand its application to a pharmacokinetic study.planta medica, 2012, 78, 244-251.
64. lei ma, wenjuan xiang, pham van khang, yang liang, yaping xiao*, lihong hu*.new dammarane-type glycosides from the roots of gynostemma pentaphyllum. planta medica, 2012, 78, 597-605.
65. min lei, lei ma*, lihong hu*. one-pot synthesis of 1h-benzimidazole derivatives using thiamine hydrochloride as a reusable organocatalyst. synthetic communications, 2012, 42, 2981-2993.
66. weibin song, peng liu, min lei, hanyun you, xubing chen, hu chen, lei ma*, lihong hu*.fecl3 and morpholine as an efficient co-catalyst for the one-step synthesis of quinoxalines from α-hydroxyketones and 1,2-diamines. synthetic communications, 2012, 42, 236-245.
67. kun zhao, min lei, lei ma, lihong hu*. a facile protocol for the synthesis of 4-aryl-1,4,7,8-tetrahydro-3,5-dimethyldipyrazolo[3,4-b:4’,3’-e]pyridine derivatives by a hantzsch-type reaction. monatshefte für chemie 2011, 142, 1169-1173.
68. min lei, lei ma*, lihong hu*.highly chemoselective condensation of β-naphthol, aldehyde, and urea catalyzed by thiamine hydrochloride. synthetic communications, 2011, 41, 3424-3432.
69. weibin song, lei ma*, lihong hu*.hclo4-sio2 as an efficient and recyclable catalyst for the synthesis of amide derivatives. synthetic communications, 2011, 41, 3186-3196.
70. min lei, lei ma*, lihong hu*.cu(clo4)2 · 6h2o as an efficient catalyst for the synthesis of 3,4-dihydropyrimidin-2(1h)-ones under solvent-free conditions. synthetic communications, 2011, 41, 3071-3077.
71. peng liu, min lei, lei ma,* lihong hu*. an efficient procedure for the synthesis of 2-aminofuran-3-carbonitriles via cascade stetter-cyclization reaction catalyzed by n-heterocyclic carbene. synlett 2011, 1133-1136.
72. min lei, lei ma*, lihong hu*. a green, efficient, and rapid procedure for the synthesis of 2-amino-3-cyano-1,4,5,6-tetrahydropyrano[3,2-c]quinolin-5-one derivatives catalyzed by ammonium acetate. tetrahedron letters, 2011, 52, 2597-2600.
73. min lei, lei ma*, lihong hu*.thiamine hydrochloride-catalyzed one-pot synthesis of 1,4-dihydropyridine derivatives under solvent-free conditions.synthetic communications, 2011, 41, 1969-1976.
74. xubing chen, jingjing zhuang, junhua liu, min lei, lei ma, jing chen, xu shen, lihong hu*. potential ampk activators of cucurbitane triterpenoids from siraitia grosvenoriiswingle. bioorganic & medicinal chemistry 2011, 19 5776–5781
75. lei ma, zhengyi yang, chenjing li, zhiyuan zhu, xu shen, lihong hu*. design, synthesis and sar study of hydroxychalcone inhibitors of human b-secretase (bace1). journal of enzyme inhibition and medicinal chemistry 2011, 26 643-648.
76. lijuan sun, jianwen liu*, ping liu*, youjun yu, lei ma, lihong hu. immunosuppression effect of withangulatin a from physalis angulata via heme oxygenase 1-dependent pathways. process biochemistry 2011, 46, 482-488.
77. lijuan sun, jianwen liu,* daling cui, jiyu li,* youjun yu, lei ma, lihong hu. anti-inflammatory function of withangulatin a by targeted inhibiting cox-2 expression via mapk and nf-kb pathways. journal of cellular biochemistry 2010, 109, 532-541.
78. youjun yu, lijuan sun, lei ma, jiyu li, lihong hu, jianwen liu*. investigation of the immunosuppressive activity of physalin h on t lymphocytes.international immunopharmacology, 2010, 10, 290-297.
79. wenjuan xiang, lei ma*, lihong hu*. neolignans and flavonoids from the root bark of illicium henryi. fitoterapia, 2010, 81, 1228-1231.
80. wenjuan xiang, chunyu guo, lei ma*, lihong hu*. dammarane-type glycosides and long chain sesquiterpene glycosides from gynostemma yixingense. fitoterapia, 2010, 81, 248-252.
81. min lei, lei ma*, lihong hu*. vb1-al2o3 catalyzed one-pot condensation of aromatic ketone, aromatic aldehyde and amide. tetrahedron letters, 2010, 51, 5746-5749.
82. min lei, lei ma*, lihong hu*. an efficient and environmentally friendly procedure for synthesis of pyrimidinone derivatives by use of a biginelli-type reaction. monatshefte für chemie 2010, 141, 1005-1008.
83. min lei, lei ma*, lihong hu*. a convenient one-pot synthesis of formamide derivatives using thiamine hydrochloride as a novel catalyst. tetrahedron letters, 2010, 51, 4186-4188.
84. min lei, lei ma*, lihong hu*. thiamine hydrochloride as an efficient catalyst for the synthesis of amidoalkyl naphthols. tetrahedron letters 2009, 50, 6393-6397.
85. wenjuan xiang, lei ma*, lihong hu*. c21 steroidal glycosides from cynanchum wilfordii. helvetica chimica acta. 2009, 92, 2659-2674.
86. haigang liu, xiong huang, guanghui xie, lei ma*, lihong hu*. one new c21 steroidal glycoside from the roots of cynanchum auriculatum. journal of china pharmaceutical university, 2009, 40, 34-36.
87. chaofeng huang, lei ma (co-first author), lijuan sun, mumtaz ali, mohammad arfan, jianwen liu*, lihong hu*. immunosuppressive withanolides from withania coagulans. chemistry & biodiversity, 2009, 6, 1415-1426.
88. xianwen gan, lei ma, qigang chen, qiuqun chen, qiang yu, lihong hu*. terpenoids from roots of chloranthus henryi. planta medica, 2009, 75, 1344–1348.
89. hao gan, wenjuan xiang, lei ma*, lihong hu*. six new c21 steroidal glycosides from cynanchum bungei decne.helvetica chimica acta, 2008, 91, 2222-2234.
90. yinhua yin, lei ma (co-first author), lihong hu*. cassane-type diterpenoids from the seeds of caesalpinia magnifoliolata.helvetica chimica acta, 2008, 91, 972-977.
91. chaofeng huang, xianwen gan, haiyun bai, lei ma, lihong hu*. schoepfin a, b, c: three new chalcone c-glycosides from schoepfia chinensis. natural product research, 2008, 22, 623-627.
92. yinan zhang, shilei zhang, lei ma, yu zhang, xu shen, wei wang, lihong hu*. total synthesis of ( )-rutamarin.advanced synthesis & catalysis, 2008, 350, 2373-2379.
93. lili wang, jianping zuo, lei ma, xiachang wang and lihong hu*. two new xanthone glycosides from ventilago leiocarpa benth. natural product communications, 2008, 3, 795-798.
94. lei ma, xianwen gan, qingping he, haiyun bai, mohammad arfan, fengchang lou, lihong hu*. cytotoxic withaphysalin from physalis minima. helvetica chimica acta, 2007, 90, 1406-1419.
95. lei ma, mumtaz ali, mohammad arfan, li-guang lou, and li-hong hu*. withaphysanolide a, a novel c-27 norwithanolide skeleton, and other cytotoxic compounds from physalis divericata. tetrahedron letters 2007, 48, 449-452.
96. guanghui xie, lei ma, zongping zheng, lihong hu*. lignana from gardneria multiflora. chinese journal of natural medicines, 2007, 5, 255-258.
97. qingping he, lei ma, jieying luo, fuyuan he, liguang lou, lihong hu*. cytotoxic withanolides from physalis angulata l.chemistry & biodiversity, 2007, 4, 443-449.
98. lei ma, fengchang lou*. the anticancer activity in vitro of constituents from fruits of sophora japonica. chinese journal of natural medicines, 2006, 4, 151-153.
99. lei ma, chuanming xie, jia li, feng-chang lou, lihong hu*. daturametelins h, i and j: three new withanolide glycosides from datura metel l. chemistry & biodiversity, 2006, 3, 180-186.
100.xianwen gan, haiyun bai, qigang chen, lei ma, lihong hu*. a zwitterionic alkaloid, containing a rare cyclopentadienyl anion unit, from the stem barks of daphniphyllum macropodum. chemistry & biodiversity, 2006, 3, 1255-1259.
101.dongmei li, lei ma, guangming liu, lihong hu*. cassane diterpene-lactones from the seed of caesalpinia minax hance. chemistry & biodiversity, 2006, 3, 1260-1265.
【教学论文及专著】
1. 孙仲颖，马小思，徐仲玉，刘朝阳，周翾，马磊. 理工结合、多学科交叉的药学三级开放实验平台的构建与实践，化工高等教育，2022, 39, 133-137.
2. 徐仲玉，马小思，刘朝阳，周 翾，马红梅，孙仲颖，马磊，黄 瑾. 药学实验教学中心硬件建设与管理探究，实验室科学，2022, 25, 162-166.
3. 徐仲玉，黄瑾，马红梅，马小思，刘朝阳，马磊. 高效液相色谱在药学类专业开放实验教学中的综合应用探索，实验室研究与探索，2021, 40, 228-231.
4. 赵建宏，杨武林，冀亚飞，袁炜，任福正，罗晓燕，马磊，任国宾，邓卫平，宋恭华. 制药工程专业实践教学新模式的探索与思考，教育现代化， 2021, 8, 35-37.
5. 马磊，参编. 药学专业实验，化学工业出版社，2020
6. 刘朝阳，徐仲玉，马小思，孙仲颖，马红梅，马磊. 工程教育认证背景下制药工程专业实验教学中渗透绿色化学理念的探索，化工高等教育，2019, (3), 6-9 76.
7. 陈晓蓓，马磊*. 新形势下高校研究生《药物波谱解析》课程建设及教学开展，课程教育研究，2019, (12), 160-161.
8. 刘朝阳，徐仲玉，马小思，孙仲颖，马红梅，马磊. 初探认知心理过程的化学实验室安全教育，教育现代化，2019, (7), 20-21 30.
9. 徐仲玉，马红梅，马小思，刘朝阳，周翾，孙仲颖，马磊. 基于短学期模式的药用仪器分析综合型实验的设计与实现，化工高等教育，2018, (3), 71-74 81.
10. 马红梅，徐仲玉，孙仲颖，马小思，刘宏伟，赵建宏，张敏，马磊. 制药工程专业本科生实验课程建设的探索与实践，化工高等教育，2018, (1), 67-71.
11. 马小思，马红梅，孙仲颖，徐仲玉，马磊. 短学期模式下交叉学科实验教学的探索，化工高等教育，2017, (6), 55-74.
12. 马小思，孙仲颖，徐仲玉，马磊. 高校化学实验室安全管理的思考，课程教育研究，2017, (2), 177-178.
13. 孙仲颖，马小思，徐仲玉，马磊. 信息化管理平台在实验教学中的应用与探讨，高教学刊，2016, 21, 147-148
14. 马磊，参编. 药用天然产物全合成-合成路线精选，华东理工大学出版社，2016.
15. 马磊，胡立宏. 生源合成途径在天然药物化学教学中的重要性探讨. 化工高等教育，2010, (3), 82-84 96.
16. 马磊，参编. 药学专业实验教程，华东理工大学出版社，2010
【专利】
1. 专利名称：具有nlrp3抑制活性的磺酰脲类衍生物及其应用；发明人：陈侠斌；马磊；侯书荣；苏孟君；孔熠超；蒋彩虹；胡英杰；黄维维；申请时间：2024.02.09；申请号：202410178529.6；范围：国内。
2. 专利名称：nlrp3 抑制活性化合物及其用途；发明人：陈侠斌，马磊，侯书荣，胡英杰，黄维维，孔熠超，张雯，蒋彩虹，苏孟君；申请时间：2024.02.09；申请号：202410178530.9；范围：国内。
3. 专利名称：nlrp3 抑制活性化合物及其用途；发明人：陈侠斌，马磊，侯书荣，胡英杰，黄维维，孔熠超，张雯，蒋彩虹，苏孟君；申请时间：2023.09.13；申请号：2023111806152.2；范围：国内。
4. 专利名称：具有jnk抑制活性的嘧啶类衍生物及其应用；发明人：陈侠斌，马磊，候书荣，黄维维，钱赫雯，黄怡，邓荇予，丁远晴，吴泽林；申请时间：2022.12.30；申请号：202211723647.8；范围：国内。
5. 专利名称：一种皮肤芯片装置；发明人：张洪波，马磊，殷瑞雪，朱金灵，李洪林，刘子佳，孙雯暄，黄琪红，杨天豪；申请时间： 2021.07.05；申请号：202110756980.8；范围：国内。
6. 专利名称：仿生肾器官芯片结构和仿生肝肾芯片结构；发明人：张洪波，马磊，殷瑞雪，朱丽丽，李洪林，黄琪红，杨天豪；申请时间：2021.05.06；申请号：202110488516.5；范围：国内。
7. 专利名称（已授权）：谷氨酰胺荧光探针及其制备方法和应用；发明人：崔佳燕；发明人：黄瑾，马磊，黄维维，邱子言；申请时间：2021.06.18；申请号：202110677752.1；授权时间：2022.09.13；范围：国内。
8. 专利名称（已授权）：治疗阿尔茨海默病的化合物；发明人：王鑫，马磊，付建军，郑秋阳，周立成，邓青芳，时夕蒙，李桂林，王世华；申请时间：2020.01.21；申请号：202010071143.7；授权时间：2022.08.30；范围：国内。已申请pct。
9. 专利名称（已授权）：3位哌嗪基查尔酮衍生物、其药物组合物及其应用；发明人：马磊，刘建文，唐赟，尹欢欢，董静静，蔡迎春，刘桂霞，时夕蒙，王皓；申请时间：2018.10.15；申请号：201811197037.2；授权时间：2020.10.02；范围：国内。
10. 专利名称（已授权，转让）：知母皂苷元结构修饰的衍生物、其药物组合物及其应用；发明人：马磊，王蕊，潘辉，董栋，赵建宏，尹欢欢，杨桂香；申请时间：2017.04.17；申请号：201710251918.7；范围：国内。授权时间：2021.1.1；
11. 专利名称（已授权，转让）：知母皂苷元结构修饰的衍生物、其药物组合物及其应用；发明人：马磊，王蕊，周南南，徐婷，赵建宏，张骥、张忠国，徐刘昕，杨雅琴，熊加伟，尹欢欢，潘辉；申请时间：2015.01.27；申请号：201710242092.8；范围：国内。授权日期：2019.8.13。
12. 专利名称（已授权）：n,n,6-三甲基-2-(4-甲基苯基)咪唑并[1,2a]吡啶-3-乙酰胺的制备方法；发明人：赵建宏，关禹，户晖，廖凡，马磊，楼开炎，张敏，赵金媛，马立荣，陈春燕；申请时间：2016.09.20，申请号：201610836205.2；范围：国内。
13. 专利名称（已授权，转让）：知母皂苷元结构修饰的衍生物、其药物组合物及其应用；发明人：马磊，王蕊，周南南，徐婷，赵建宏，张骥、张忠国，徐刘昕，杨雅琴，熊加伟，尹欢欢，潘辉；申请时间：2015.01.27；申请号：201510042229.6；范围：国内，授权日期：2017.12.22。
14. 专利名称：微流控设备及成像检测装置；发明人：张洪波，马磊，殷瑞雪，朱丽丽，李洪林，刘子佳，黄琪红，杨天豪，何嘉琪，徐源洪，章立；申请时间：2021.3.22；申请号：202110300268.7；范围：国内。
15. 专利名称：前远志皂苷元衍生物、其药物组合物及其应用；发明人：马磊，王蕊，杨桂香，黄维维，黄怡；申请时间：2020.10.23；申请号：202011143471.x；范围：国内。
16. 专利名称：胡椒碱及其衍生物在制备治疗自身免疫性疾病的药物中的应用；发明人：黄瑾，卢伟强，刘泽慧，马磊；申请时间：2020.02.28；申请号：202010126999.x；范围：国内。
17. 专利名称（授权）：甾体皂苷元衍生物及其制备方法和应用；发明人：马磊，王蕊，杨桂香，李洁，李诗良，付建军，范文康（pham van khang），章立，苏琳；申请时间：2019.04.18；申请号：201910315200.9；范围：国内。授权日期：2023.4.26
18. 专利名称：羟基氯喹衍生物及其制备方法、应用；发明人：赵建宏，陈春燕，马立荣，赵金媛，马磊，李杰，杨俊，雷青云，蔡基伟，刘子越；申请时间：2018.08.01；申请号：201810865097.0；范围：国内。
19. 专利名称：薯蓣皂苷元衍生物、其药物组合物及其应用；发明人：马磊，王蕊，杨桂香，毛宇，吴艳，黄艳，甘海贤，李洁，张聪；申请时间：2018.09.27；申请号：201811128431.0；范围：国内。
20. 专利名称：β-芳香基硫醚取代的α,β-环烯酮衍生物及其制备方法和应用；发明人：郑剑斌、李佳、周宇波、马磊、彭延敏、曹现超；申请时间：2014.10.10；申请号：201410531378.4；范围：国内。
21. 专利名称：一种分离富集并同时检测饮用水源水中12种抗生素的方法；发明人：崔长征，张东，程文欢，卢宁，马磊，姜蕾，林匡飞，孙晓燕，石杰，薛佳怡，金磊，李志杰，黄玲；申请时间：2014.12.08；申请号：201410735911.9；范围：国内。
22. 专利名称：含withanolide型化合物的免疫抑制剂；发明人：马磊、刘建文、胡立宏、孙丽娟、于有军；申请时间：2007.11.2；申请号：200710047733.0；范围：国内。cn101422467
23. 专利名称：线型呋喃香豆素衍生物、其制备方法和用途以及包含该衍生物的药物组合物；发明人：胡立宏、沈旭、蒋华良、张余、马磊；申请时间：2007.05.16；申请号：200710040733.8；范围：国内。cn101307056
【承担项目】
1. 新药专利转让项目，转让金额3125万及销售提成1%，2018.3 -2035.5，主持
2. 国家自然科学基金面上项目（82373739），2024.1-2027.12，主持
3. 国家自然科学基金面上项目（81973196），2020.1-2023.12，主持
4. 国家自然科学基金面上项目（81673318），2017.1-2020.12，主持
5. 国家自然科学基金青年项目（21002027），2011.1-2013.12，主持
6. 国家自然科学基金原创探索计划项目（32150030），2022.1 -2024.12，骨干
7. 国家科技重大专项（2018zx09735002），2018.1 -2021.12，骨干
8. 上海市生物医药支撑计划项目（15401901100），2015.9-2018.8，主持
9. 上海市浦江人才计划项目（15pjd012），2015.9-2017.8，主持
10. 上海市自然科学基金年项目（15zr1408800），2015.1-2017.12主持
11. 上海市联盟计划难题招标专项，2010.6-2011.5，主持
12. 上海市药学实践工作站项目，2020年度，2021年度，2022年度，主持
13. 上海市市级科技重大专项重大项目，2020.1 -2023.12，骨干
【本实验室毕业研究生去向】
雷 敏（博）中国科学院上海药物研究所
宋维彬（博）南京中医药大学
杨桂香（博）华东理工大学
马 飞（博）上海科技大学
陈旭冰（硕）大理大学
沈思达（博）美国西北大学
尹欢欢（博）齐鲁工业大学
谢光辉（硕）郑州工程技术学院
巩馥玮（硕）齐鲁医药学院
葛松兰（硕）辉瑞（中国）研究开发有限公司
程文欢（硕）昆泰企业管理（上海）有限公司
向文娟（博）芬美意香料（中国）有限公司
孙晓燕（硕）益新国际医药科技有限公司
薛佳怡（硕）默沙东研发（中国）有限公司
王 皓（硕）上海微创电生理医疗科技股份有限公司
吴 艳（硕）上海复宏汉霖生物技术股份有限公司
王琦琦（硕）和记黄埔医药上海有限公司
潘 辉（硕）上海睿智化学研究有限公司
熊加伟（硕）南京药石科技股份有限公司
干 浩（硕）天津红日药业股份有限公司
陈 虎（博）浙江越甲药业有限公司
刘军华（博）广东众生药业股份有限公司
徐 婷（硕）江苏豪森药业集团有限公司
刘海港（硕）上海恒瑞医药有限公司
刘 鹏（博）上海合全药物研发有限公司
尤晗昀（博）浙江普洛康裕制药有限公司
张忠国（硕）瑞阳（上海）新药研发有限公司
郭春雨（硕）北京峨兰斯科技有限公司
杨雅琴（硕）四川科伦药业股份有限公司
陆瑶琦（硕）药明康德新药开发有限公司
