associate professor xin liang-全讯国际

contact information

• office:room 633, researching building 18

• email:

• office phone: 86 21 6425 2262

• office fax: 86 21 6425 2262

education

• 2012.03 ph.d.biochemical engineering, east china university of science&technology, shanghai, p. r. china

• 2007.06 b.sc.bioengineering, east china university of science&technology, shanghai, p. r. china

professional experience

• 2016-now   associate professor school of pharmacy, east china universtiy of science and technology, shanghai, p. r. china

• 2015-2016   instructor school of pharmacy, east china universtiy of science and technology, shanghai, p. r. china

• 2012-2015   postdoctoral fellow aflac cancer and blood disorders center, dept of pediatrics, school of medicine, emory university, atlanta, ga, usa

research interests

• the mechanism of platelet membrane glycoprotein participates in the tumor metastatic process

• the interaction of mirna in tumor metastasis and microenvironment.

publication

1. xu k*, zhan y, yuan z, qiu y, wang h, fan g, wang j, li w, cao y, shen x, zhang j, liang x*, yin p*. hypoxia induces drug resistance in colorectal cancer through the hif-1α/mir-338-5p/il-6 feedback loop.molecular therapy. 2019, 27(10):1810-1824.

2. qi y, chen w, liang x, xu k*, gu x, wu f, fan x, ren s, liu j, zhang j, li r, liu j*, liang x*. novel antibodies against gpibα inhibit pulmonary metastasis by affecting vwf-gpibα interaction. journal of hematology & oncology. 2018, 11(1):117.

3. liang x, chen w, shi h, gu x, li y, qi y, xu k^*, zhao a^*, liu j^*. ptbp3 contributes to the metastasis of gastric cancer by mediating cav1 alternative splicing. cell death & disease. 2018, 9:569.

4. liang x, shi h, yang l, qiu c, lin s, qi y, li j^*, zhao a^*, liu j^*. inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells. br j cancer. 2017, 116(7):903-911.

5. liang x, wang j, chen w, ma x, wang y, nagao n, weng w^*, huang j^*, liu j^*. inhibition of airway remodeling and inflammation by isoforskolin in pdgf-induced rat asmcs and ova-induced rat asthma model. biomed pharmacother. 2017;95:275-286.

6. xu k, chen g, li x, wu x, chang z, xu j, zhu y, yin p, liang x^*, dong l^*. mfn2 suppresses cancer progression through inhibition of mtorc2/akt signaling. sci rep. 2017, 7:41718.

7. lin s, yang l, shi h, du w, qi y, qiu c, liang x^*, shi w^*, liu j^*. endoplasmic reticulum-targeting photosensitizer hypericin confers chemo-sensitization towards oxaliplatin through inducing pro-death autophagy. int j biochem cell biol. 2017;87: 54-68.

8. chen w, ma x, zhang p, li q, liang x^*, liu j^*. mir-212-3p inhibits lps-induced inflammatory response through targeting hmgb1 in murine macrophages. exp cell res. 2017, 350(2):318-26.

9. chen w¹, liang x¹, syed ak, jessup p, church wr, ware j, josephson cd, li r^*. inhibiting gpibα shedding preserves post-transfusion recovery and hemostatic function of platelets after prolonged storage. arterioscler thromb vasc biol. 2016, 36(9):1821-8.

10. liang x, syed ak, russell sr, ware j, li r^*. dimerization of glycoprotein ib is not sufficient to induce platelet clearance. j thromb haemost. 2016,14: 381-6.

11. li q¹, liang x¹, wang y, meng x, xu y, cai s, wang z^*, liu j^*, cai g^*. mir-139-5p inhibits the epithelial- mesenchymal transition and enhances the chemotherapeutic sensitivity of colorectal cancer cells by downregulating bcl2. sci rep. 2016, 6: 27157.

12. zou f, mao r, yang l, lin s, lei k, zheng y, ding y, zhang p, cai g^*, liang x^*, liu j^*. targeted deletion of mir-139-5p activates mapk, nf-kb and stat3 signaling and promotes intestinal inflammation and colorectal cancer. febs j. 2016, 283(8): 1438-52.

13. lei k, du w, lin s, yang l, xu y, gao y, xu b, tan s, xu y, qian x, liang x^*, liu j^*. 3b, a novel photosensitizer, inhibits glycolysis and inflammation via mir-155-5p and breaks the jak/stat3/socs1 feedback loop in human breast cancer cells. biomed pharmacother. 2016, 82: 141-50.

14. zheng y, yin g, le v, zhang a, chen s, liang x^*, liu j^*. photodynamic-therapy activates immune response by disrupting immunity homeostasis of tumor cells, which generates vaccine for cancer therapy. int j biol sci. 2016, 12(1): 120-32.

15. lin s, lei k, du w, yang l, shi h, gao y, yin p^*, liang x^*, liu j^*. enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ros-related mechanism. int j biochem cell biol. 2016, 71:24-34.

16. mao r, zou f, yang l, lin s, li y, ma m, yin p^*, liang x^*, liu j^*. the loss of mir-139-5p promotes colitis-associated tumorigenesis by mediating pi3k/akt/wnt signaling. int j biochem cell biol. 2015, 69: 153-61.

17. liang x, russell sr, estelle s, jones lh, cho s, kahn ml, berndt mc, bunting st, ware j, li r^*. specific inhibition of ectodomain shedding of glycoprotein ibα by targeting its juxtamembrane shedding cleavage site. j thromb haemost. 2013, 11(12): 2155-62.