谢贺新
教授，博士生导师
电话：021-64252269
email :
课题组网页：https://www.x-mol.com/groups/xiehexin
址：上海市徐汇区梅陇路130号实验14楼西501室
个人简介
1998年毕业于上海复旦大学化学系，获理学学士学位。后到中国科学院上海有机化学研究所金属有机国家重点实验室工作。2008年毕业于美国新墨西哥大学化学与化学生物学系，获理学博士学位。2009年1月至2012年12月间，在美国斯坦福大学医学院分子影像中心（mips）从事博士后研究。2013年1月加入华东理工大学药学院药物科学系。
研究成果
谢贺新的主要研究兴趣包括有机化学，药物化学及化学生物学,分子影像等交叉学科领域。迄今为止，共在sci收录的国际期刊杂志发表论文60余篇，其中包括nature chem.，nature commun.，j. am. chem. soc.，angew. chem. int. ed.等知名期刊。多篇论文被nature,c&e news(美国化学化工新闻)，chemistryviews，chemcatchem，scientific american等期刊、网站等作专文评论、介绍。
研究方向
1.化学生物学
以有机合成为基础，发展以生物体系中重要的酶蛋白为靶标的分子探针，应用于疾病的快速诊断、药物活性筛选模型的建立及细胞荧光成像中。
2.药物化学
针对致病细菌抗生素耐药日益严峻的情况，发展针对耐药菌的新型抗生素及酶抑制剂。
代表性论文
1. mao, w.; xia, l.; xie, h.* “detection of carbapenemase-producing organisms with a carbapenem-based fluorogenic probe” angew. chem. int. ed. 2017, 56, 4468. (hot paper). (if = 11.709)
2. huang, h.; yu, c.; li, x.; zhang, y.; zhang, y.; chen, x.; mariano, p. s.*; xie, h.*; wang, w.* “synthesis of aldehydes by organocatalytic formylation reactions of boronic acids with glyoxylic acid” angew. chem. int. ed.2017, 56, 8201 (if = 11.709)
3. .mao, w.; xia, l.; wang, y.; xie, h.* “a self-immobilizing and fluorogenic probe for β-lactamases detection”chem. asian j. 2016, 11, 3493 (if = 4.592)
4. zhou, d.; huang, z.; yu, x.; wang, y.; li, j.; wang, w*; xie, h.* “a quinine-squaramide catalyzed enantioselective aza-friedel-crafts reaction of cyclic trifluoromethyl ketimines with naphthols and electron-rich phenols”org. lett., 2015, 17, 5554. (if = 6.732)
5. cheng, y.#; xie, h.#; sule, p.; hassounah, h.; graviss, e. a.; kong, y.; cirillo, j. d. and rao, j.* “fluorogenic probes with substitutions at the 2 and 7 positions of cephalosporin are highly blac-specific for rapid mycobacterium tuberculosis detection”angew. chem. int. ed.,2014,53, 9360.(reported by “cheap test slashes time taken to diagnose tb”,nature doi: 10.1038/nature.2014.15503) . (if = 11.709)
6. xie, h.#, mire, j.#, kong, y.#,chang, m.,hassounah, h., thornton, c.n., sacchettini, j. c., cirillo, j. d., rao, j.* "rapid point-of-care detection of the tuberculosis pathogen using a blac-specific fluorogenic probe",nature. chem.2012, 4,802.(reported by nature (doi:10.1038/nature.2012. 11327) and scientific american). (if = 27.893)
7. xie, h.; zhang, y.; zhang, s.; chen, x.; wang, w.* "bifunctional cinchona alkaloid thiourea catalyzed highly efficient, enantioselective aza-henry reaction of cyclic trifluoromethyl ketimines: synthesis of anti-hiv drug dpc 083"angew. chem. int. ed.,2011, 50, 11773. (if = 11.709)
8. zhang, s.-l.#,xie, h.#; zhu, j.; li, h.; zhang, x.-s.; li, j.*; wang, w.*, “organocatalytic enantioselective β-functionalization of aldehydes by oxidation of enamines and their application in cascade reactions”nature. commun.2011,2,211-218. (reported by c&e news (2011,89(10), 9), chemcatchem(2012,4, 612) and synfacts (2011, 5, 0560)) (if = 11.329)
9. xie, h.; zu, l.; li, h.; wang, j.; wang, w.* “organocatalytic enantioselective cascade michael-alkylation reactions: synthesis of chiral cyclopropanes and investigation of unexpected organocatalyzed stereoselective ring opening of cyclopropanes”,j. am. chem. soc.,2007,129, 10886. (if = 13.038)
#co-first author, * correspondence author
