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professor you yang
发布时间:2019-05-20   访问次数:690   作者:


contact information

  • office: room 1035a, researching building 18

  • email:

  • office phone: 86 21 6425 3851

education

  • 2010.0 ph.d.  organic chemistry, university of science and technology of china (ustc), hefei, p. r. china

  • 2004.06  b.s.  chemistry, university of science and technology of china (ustc), hefei, p. r. china

professional experience

  • 2015.09-now  professor, east china university of science and technology (ecust), shanghai, china

  • 2014.09-2018.08  associate professor, east china university of science and technology (ecust), shanghai, china

  • 2010.08-2014.06  postdoctoral fellow, max planck institute of colloids and interfaces, berlin, germany

research interests

  • synthetic methodology, total synthesis, and chemical biology of biologically significant carbohydrates and glycoconjugates

  • development of carbohydrate-based drugs and vaccines

  • interactions of carbohydrates and proteins for the application in new diagnostic tools

publication

33. wang, x.; chen, y.; wang, j.; yang, y.* total synthesis of the trisaccharide antigen of the campylobacter jejuni rm1221 capsular polysaccharide via de novo synthesis of the 6-deoxy-d-manno-heptose building blocks. j. org. chem. 2019, 84, 2393−2403. (: co-first author)

  • cover

32. zhuang, l.; chen, y.; lou, q.; yang, y.* synthesis of the -linked galnac-kdo disaccharide antigen of the capsular polysaccharide of kingella kingae kk01. org. biomol. chem.2019, 17, 1694–1697.

  • outside front cover

31. geissner, a.; reinhardt, a.; rademacher, c.; johannssen, t.; monteiro, j.; lepenies, b.; thepaut, m.; fieschi, f.; mrazkova, j.; wimmerova, m.; schuhmacher, f.; götze, s.; grünstein, d.; guo, x.; hahm, h. s.; kandasamy, j.; leonori, d.; martin, c. e.; parameswarappa, s. g.; pasari, s.; schlegel, m. k.; tanaka, h.; xiao, g.; yang, y.; pereira, c. l.; anish, c.; seeberger, p. h.* microbe-focused glycan array screening platform. proc. natl. acad. sci. usa.2019, 116, 19581967.

30. fan, w.; chen, y.; lou, q.; zhuang, l.; yang, y.* synthesis of 3-c-branched kdo analogues via sonogashira coupling of 3-iodo kdo glycal with terminal alkynes. j. org. chem. 2018, 83, 6171–6177.

  • highlighted by chembeango (may 28, 2018).

29. hu, x.; wang, d.; tong, y.; tong, l.; wang, x.; zhu, l.; xie, h.; li, s.; yang, y.*, xu, y.* design, synthesis and evaluation of ribose-modified anilinopyrimidine derivatives as egfr tyrosine kinase inhibitors. front. chem.2017, 5, 101.

28. yang, y.*, yu, b.* recent advances in the chemical synthesis of c-glycosides. chem. rev. 2017, 117, 12281–12356.

  • most read articles in october, 2017.

  • esi “highly cited paper”

27. mi, x.; lou, q.; fan, w.; zhuang, l.; yang, y.* gold(i)-catalyzed synthesis of -kdo glycosides using kdo ortho-hexynylbenzoate as donor. carbohydr. res.2017, 448, 161–165.

26. wang, j.; liu, r.; yang, y.* rapid and efficient conversion of sialyl thioglycosides to sialyl esters via nis/bf3oet2-promoted glycosylation. tetrahedron lett. 2017, 58, 2370–2373.

25. chen, y.; wang, x.; wang, j.; yang, y.* synthesis of d-manno-heptulose via a cascade aldol/hemiketalization reaction. beilstein j. org. chem.2017, 13, 795–799.

24. wang, j.; mi, x.; wang, j.; yang, y.* an efficient approach to chloro(organophosphine) gold(i) complexes for the synthesis of auranofin. green chem.2017, 19, 634–637.

23. reinhardt, a.; wehle, m.; geissner, a.; crouch, e. c.; kang, y.; yang, y.; anish, c.; santer, m.;* seeberger, p. h.* structure binding relationship of human surfactant protein d and various lipopolysaccharide inner core structures. j. struct. biol. 2016, 195, 387–395.

22. chen, x.; shen, d.; wang, q.; yang, y.; yu, b.* ortho-(methyltosylaminoethynyl)benzyl glycosides as new glycosyl donors for latent-active glycosylation. chem. commun. 2015, 51, 13957–13960.

21. yang, y.;* zhang, x.; yu, b.* o-glycosylation methods in the total synthesis of complex natural glycosides. nat. prod. rep. 2015, 32, 1331–1355.

  • esi “highly cited paper”

  • abstracted by cheminform 2015, 43-237

20. yang, y.;* lian, g.; yu, b.* naturally occurring polyphenolic glucosidase inhibitors. isr. j. chem. 2015, 55, 268–284. (chi-huey wong  wolf prize special issue)

  • abstracted by cheminform 2015, 24-287

19. reinhardt, a.;yang, y.; claus, h.; pereira, c. l.; cox, a. d.; vogel, u.; anish, c.;* seeberger, p. h.* antigenic potential of a highly conserved neisseria meningitidis lipopolysaccharide inner core structure defined by synthetic approach. chem. biol.2015, 22, 38–49. (: co-first author)

18. yang, y.;* laval, s.; yu, b.* chemical synthesis of saponins. in adv. carbohydr. chem. biochem. academic press, 2014, 71, 137–226.

17. xu, p.; xu, w.; dai, y.; yang, y.; yu, b.* efficient synthesis of a library of heparin tri- and tetrasaccharides relevant to the substrate of heparanase. org.chem. front.2014, 1, 405–414.

16. broecker, f.; aretz, j.; yang, y.; hanske, j.; guo, x.; reinhardt, a.; wahlbrink, a.; rademacher, c.; anish, c.;* seeberger, p. h.* epitope recognition of antibodies against a yersinia pestis lipopolysaccharide trisaccharide component. acs chem. biol.2014, 9, 867–873.

15. yang, y.;* yu, b.* recent advances in the synthesis of chitooligosaccharides and congeners. tetrahedron2014, 70, 1023–1046.

  • abstracted by cheminform 2014, 17-257

14. yang, y.; oishi, s.; martin, c. e.; seeberger, p. h.* diversity-oriented synthesis of inner core oligosaccharides of the lipopolysaccharide of pathogenic gram-negative bacteria. j. am. chem. soc.2013, 135, 6262–6271.

13. yang, y.; martin, c. e.; seeberger, p. h.* total synthesis of the core tetrasaccharide of neisseria meningitidis lipopolysaccharide, a potential vaccine candidate for meningococcal diseases. chem. sci.2012, 3, 896899.

  • broadcasted by deutschlandfunk(30 dec. 2011)

  • highlighted in chemistry world (february 2012)

12. yang, y.;  liu, t.;  yang, y.; wu, q.;yang, q.;* yu, b.* synthesis, evaluation, and mechanism of n,n,n-trimethyl-d-glucosamine-(1→4)-chitooligosaccharides as selective inhibitors of glycosyl hydrolase family 20 -n-acetyl-d-hexosaminidases.chembiochem2011, 12, 457–467. (: co-first author)

11. yang, y.; li, y.; yu, b.* chemoselective glycosylation of carboxylic acid with glycosyl ortho-hexynylbenzoates as donors. tetrahedron lett.2010, 51, 1504–1507.

10. li, y.; yang, x.; liu, y.; zhu, c.; yang, y.; yu, b.* gold(i)-catalyzed glycosylation with glycosyl ortho-alkynylbenzoates as donors, general scope and application to the synthesis of a cyclic triterpene saponin. chem. eur. j.2010, 16, 1871–1882.

  • abstracted by cheminform 2010, 24-183

9. yang, y.; li, y.; yu, b.* total synthesis and structure revision of tmg-chitotriomycin, a specific inhibitor of insect and fungal -n-acetylglucosaminidases. j. am. chem. soc.2009, 131, 12076–12077.

  • highlighted in chin. j. org. chem.2009, 29, 1867

  • abstracted by cheminform 2009, 51-199

8. li, y.; yang, y.; yu, b.*an efficient glycosylation protocol with glycosyl ortho-alkynylbenzoates as donors under the catalysis of pph3auotf. tetrahedron lett.2008, 49, 3604–3608.

  • abstracted by cheminform 2008, 36-196

7. yang, y.; yu, b.* n-dimethylphosphoryl-protection in the efficient synthesis of glucosamine-containing oligosaccharides with alternate n-acyl substitutions. tetrahedron lett.2007, 48, 7049–7052.

6. yang, y.; yu, b.*n-dimethylphosphoryl-protected glucosamine trichloroacetimidate as an effective glycosylation donor.tetrahedron lett.2007, 48,4557–4560.

  • abstracted by cheminform 2007, 41-173

5. liu, z.; hu, z.; liang, j.; li, s.; yang, y.; peng, s.; qian, y.* size-controlled synthesis and growth mechanism of monodisperse tellurium nanorods by a surfactant-assisted method. langmuir2004, 20, 214218.

4. liu, z.; li, s.; yang, y.; peng, s.; hu, z.; qian, y.* complex-surfactant-assisted hydrothermal route to ferromagnetic nickel nanobelts. adv. mater.2003, 15, 19461948.

3. liu, z.; peng, s.; xie, q.; hu, z.; yang, y.; zhang, s.; qian, y.* large-scale synthesis of ultralong bi2s3 nanoribbons via a solvothermal process. adv. mater.2003, 15, 936940.

2. liu, z.; li, s.; yang, y.; hu, z.; peng, s.; liang, j.; qian, y.* shape-controlled synthesis and growth mechanism of one-dimensional nanostructures of trigonal tellurium. new j. chem.2003, 27, 17481752.

1. liu, z.; yang, y.; liang, j.; hu, z.; li, s.; peng, s.; qian, y.*

synthesis of copper nanowires via a complex-surfactant-assisted hydrothermal reduction. j. phys. chem. b2003, 107, 1265812661.

  • abstracted by cheminform 2004, 16-207




 
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