professor jian li-全讯国际

director

office of strategic planning and discipline construction

contact information

• office: room 1223, researching building 18

• email:

• office phone: 86 21 64252584

• office fax: 86 21 64252584

education

• 09/2003-07/2006  ph.d.  drug design, shanghai institute of materia medica  (simm), chinese academy of science (cas), shanghai, china

• 09/2000-07/2003  m.s.  medicinal chemistry, shenyang pharmaceutical university, shenyang, china

• 09/1996-07/2000  b.e.  pharmaceutical chemistry, shenyang pharmaceutical university, shenyang, china

professional experience

• 05/2018-now  professor, director of office of strategic planning and discipline construction, east china university of science & technology, shanghai, china

• 05/2017-05/2018  professor, secretary of the party committee of school of pharmacy, east china university of science & technology, shanghai, china

• 09/2015-07/2017  professor, vice dean of school of pharmacy, east china university of science & technology, shanghai, china

• 09/2011-09/2015  professor, director of department of pharmaceutical sciences, school of pharmacy, east china university of science & technology, shanghai, china

• 03/2011-09/2011  associate professor, director of department of pharmaceutical sciences, school of pharmacy, east china university of science & technology, shanghai, china

• 12/2006-03/2011  associate professor, school of pharmacy, east china university of science & technology, shanghai, china

• 07/2006-12/2006  lecturer, school of pharmacy, east china university of science & technology, shanghai, china

research interests

• the secondary development of approved drugs

• discovery of unknown targets and new derivatives of approved drug probe

• novel anti-mrsa therapeutic agents targetting on bacterial virulence

publication

1. baoli li^#; shuaishuai ni^#; fei mao^#; feifei chen; yifu liu; hanwen wei; wenhua chen; jin zhu; lefu lan*; jian li*, novel terminal bipheny-based diapophytoene desaturases (crtn) inhibitors as anti-mrsa/visr/lrsa agents with reduced herg activity, journal of medicinal chemistry, 2018, 61(1): 224~250.

2. yifu liu^#; zuoquan xie^#; dan zhao; jin zhu; fei mao; shuai tang; hui xu; cheng luo; meiyu geng; min huang*; jian li*, development of the first generation of disulfide-based subtype-selective and potent covalent pyruvate dehydrogenase kinase 1 (pdk1) inhibitors, journal of medicinal chemistry, 2017, 60(6): 2227~2244.

3. yanli lu^#; fei mao^#; xiaokang li; xinyu zheng; manjiong wang; qing xu; jin zhu; jian li*, discovery of potent, selective stem cell factor receptor/platelet derived growth factor receptor alpha (c-kit/pdgfrα) dual inhibitor for the treatment of imatinib-resistant gastrointestinal stromal tumors (gists), journal of medicinal chemistry, 2017, 60(12): 5099~5119.

4. shuaishuai ni^#; hanwen wei^#; baoli li^#; feifei chen; yifu liu; wenhua chen; yixiang xu; xiaoxia qiu; xiaokang li; yanli lu; wenwen liu; linhao hu; dazheng lin; manjiong wang; xinyu zheng; fei mao; jin zhu; lefu lan*; jian li*, novel inhibitors of staphyloxanthin virulence factor in comparison with linezolid and vancomycin versus methicillin-resistant, linezolid-resistant, and vancomycin-intermediate staphylococcus aureus infections in vivo, journal of medicinal chemistry, 2017, 60(19): 8145~8159.

5. weiqiang lu^#; feixiong cheng^#; wenzhong yan^#; xi li; xue yao; wenqiang song; mingyao liu; xu shen; hualiang jiang; jin chen; jian li*; jin huang*, selectivetargeting p53wt lung cancer cells harboring homozygous p53 arg72 byan inhibitor of cypa, oncogene, 2017, 36(33): 4719~4731.

6. feifei chen^#; hongxia di^#; youxin wang^#; qiao cao; bin xu; xue zhang; nana yang; guijie liu; cai-guang yang; yong xu; hualiang jiang; fulin lian; naixia zhang; jian li*; lefu lan*, small-molecule targeting of a diapophytoene desaturase inhibits s. aureus virulence, nature chemical biology, 2016, 12(3): 174~179.

7. youxin wang^#; feifei chen^#; hongxia di; yong xu; qiang xiao; xuehai wang; hanwen wei; yanli lu; lingling zhang; jin zhu; chunquan sheng; lefu lan*; jian li*, discovery of potent benzofuran-derived diapophytoene desaturase (crtn) inhibitors with enhanced oral bioavailability for the treatment of methicillin-resistant staphylococcus aureus (mrsa) infections, journal of medicinal chemistry, 2016, 59(7): 3215~3230.

8. youxin wang^#; hongxia di^#; feifei chen; yong xu; qiang xiao; xuehai wang; hanwen wei; yanli lu; lingling zhang; jin zhu; lefu lan*; jian li*, discovery of benzocycloalkane derivatives efficiently blocking bacterial virulence for the treatment of methicillin-resistant s. aureus (mrsa) infections by targeting diapophytoene desaturase (crtn), journal of medicinal chemistry, 2016, 59(10): 4831~4848.

9. wenyi sun^#; zuoquan xie^#; yifu liu^#; dan zhao^#; zhixiang wu; dadong zhang; hao lv; shuai tang; nan jin; hualiang jiang; minjia tan; jian ding; cheng luo*; jian li*; min huang*; meiyu geng*, jx06 selectively inhibits pyruvate dehydrogenase kinase pdk1 by a covalent cysteine modification, cancer research, 2015, 75(22): 4923~4936.

10. huang huang; wenhua chen; yong xu; jian li*, i−/tbhp catalyzed csp3–n/csp2–n bond formation via oxidative coupling with benzophenone imine in water, green chemistry, 2015, 17(10): 4715~4719.